新規アダプタータンパク質STAP-2の免疫シグナルにおける機能

Sekine, Yuichi

新規アダプタータンパク質STAP-2の免疫シグナルにおける機能

Sekine, Yuichi

Yakugaku Zasshi, 2010, 130(6), 769-775

Permalink : https://hdl.handle.net/2115/44421

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アクセス権	open access
URI	https://hdl.handle.net/2115/44421
タイトル	新規アダプタータンパク質STAP-2の免疫シグナルにおける機能
著者	著者名 Sekine, Yuichi
言語	日本語
キーワード	signal-transducing adaptor protein-2 (STAP-2)
	adaptor protein
	cytokine
	signal transduction
	immune system
発行日	2010
収録物名	Yakugaku Zasshi
巻(号)	130(6)
ページ	769-775
抄録	Signal-transducing adaptor protein-2 (STAP-2) was recently identified as a novel adaptor protein and is a family of STAP adaptor protein and has a variety of functions in cellular signal transductions. Especially STAP-2 has a crucial role in immune systems by controlling cytokine signal transduction. STAP-2 functionally interacts with STAT3 through its YXXQ motif and enhances STAT3 transcriptional activation. In contrast, STAP-2 interacts with STAT5 through its PH and SH2-like domains and decreases STAT5 activity. Importantly, STAP-2 also binds to MyD88 and IKK-α/β and regulates LPS/TLR4 signaling. Moreover, STAP-2 interacts with Epstein-Barr virus-derived LMP1 and modulates LMP1-mediated NF-κB signaling. More importantly, experiments using STAP-2 deficient mice showed that STAP-2 modulated several T-cell functions. T-cells from STAP-2 deficient mice showed enhanced integrin-mediated cell adhesion to fibronectin. Furthermore STAP-2-deficient T-cells show reduced chemotaxis toward SDF-1α. These accumulated evidences indicate that novel adaptor protein STAP-2 plays an important modulator role in both of innate and adaptive immune systems.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0031-6903
EISSN	1347-5231
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/yakushi.130.769