Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction

Chen, Yong Mei; Kurokawa, Takayuki; Tominaga, Taiki; Yasuda, Kazunori; Osada, Yoshihito; Gong, Jian Ping; Yamamoto, Kimiko; Ando, Joji

Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction

Chen, Yong Mei; Kurokawa, Takayuki; Tominaga, Taiki et al.

Advanced Engineering Materials, 2010, 12(11), B628-B636

Permalink : https://hdl.handle.net/2115/44824

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/44824
タイトル	Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction
著者	Chen, Yong Mei ; Kurokawa, Takayuki ; Tominaga, Taiki ; Yasuda, Kazunori ; Osada, Yoshihito ; Gong, Jian Ping ; Yamamoto, Kimiko ; Ando, Joji
著者名 Chen, Yong Mei
e-Rad_Researcher 40451439 著者名 Kurokawa, Takayuki
著者名 Tominaga, Taiki
e-Rad_Researcher 20166507 著者名 Yasuda, Kazunori
e-Rad_Researcher 60007804 著者名 Osada, Yoshihito
e-Rad_Researcher 20250417 著者名 Gong, Jian Ping
著者名 Yamamoto, Kimiko
著者名 Ando, Joji
言語	英語
キーワード	Friction
	Endothelial cell
	Glycocalyx
	Gel scaffold
	Lubrication
発行日	2010-11-17
出版者	WILEY
収録物名	Advanced Engineering Materials
巻(号)	12(11)
ページ	B628-B636
抄録	In this study, we investigated the sliding friction of human umbilical vein endothelial cell (HUVEC) monolayer cultured on poly(sodium p-styrene sulfonate) (PNaSS) gel, intending to elucidate the role of the glycocalyx on the surface of endothelial cell (EC) in friction reduction. Three sets of HUVEC monolayers were investigated: 1) as-cultured HUVEC monolayer, 2) HUVEC monolayer treated by transforming growth factor υ1 (TGF-υ1), which increased glycocalyx by 148%, 3) HUVEC monolayer treated by heparinase I, which reduced glycocalyx by 57%, both were compared with that of the as prepared one. When being slid on flat glass surface, the frictional stress of HUVEC monolayer decreased in the order of heparinase I-treated > as-cultured > TGF-υ1-treated samples. The results suggested that glycocalyx may play a role in reducing the friction of endothelial cell monolayer.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1438-1656
EISSN	1527-2648
NCID	AA11613550
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/adem.201080021