Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas

Kanai, Motoshi; Hamada, Jun-Ichi; Takada, Minoru; Asano, Toshimichi; Murakawa, Katsuhiko; Takahashi, Yoko; Murai, Taichi; Tada, Mitsuhiro; Miyamoto, Masaki; Kondo, Satoshi; Moriuchi, Tetsuya

Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas

Kanai, Motoshi; Hamada, Jun-Ichi; Takada, Minoru et al.

Oncology Reports, 2010, 23(3), 843-851

Permalink : https://hdl.handle.net/2115/44898

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アクセス権	open access
URI	https://hdl.handle.net/2115/44898
タイトル	Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas
著者	Kanai, Motoshi ; Hamada, Jun-Ichi ; Takada, Minoru ; Asano, Toshimichi ; Murakawa, Katsuhiko ; Takahashi, Yoko ; Murai, Taichi ; Tada, Mitsuhiro ; Miyamoto, Masaki ; Kondo, Satoshi ; Moriuchi, Tetsuya
著者名 Kanai, Motoshi
著者名 Hamada, Jun-Ichi
著者名 Takada, Minoru
著者名 Asano, Toshimichi
著者名 Murakawa, Katsuhiko
著者名 Takahashi, Yoko
著者名 Murai, Taichi
著者名 Tada, Mitsuhiro
著者名 Miyamoto, Masaki
著者名 Kondo, Satoshi
著者名 Moriuchi, Tetsuya
言語	英語
発行日	2010-03
出版者	Spandidos Publications
収録物名	Oncology Reports
巻(号)	23(3)
ページ	843-851
抄録	HOX genes are known as master regulator genes which give cells positional information in embryogenesis. In this Study, we compared the expression patterns of 39 HOX genes among human colorectal carcinomas from the right large intestine (cecum, ascending and transverse colon), those from the left large intestine (discending and sigmoid colon, and rectum) and hepatocellular carcinoma. The expression levels of each HOX gene were quantified by analysis based on the real-time RT-PCR. The expression patterns of HOX genes in colorectal and hepatocellular carcinoma tissues differed from those in their normal or non-cancerous tissues. Between the tumor tissues in the right-side large intestine and those in the left-side. different HOX genes were expressed in association with cancer. Further, the expression levels of HOXD8 in liver-metastatic tissues of colorectal carcinomas were as low as in non-cancerous liver tissues, and were significantly lower than those in the primary tissues. These results suggest that dysregulated expressions of HOX genes play an important role in carcinogenesis and malignant progression of colorectal and hepatocellular carcinomas.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1021-335X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/or_00000706