Critical roles of mecamylamine-sensitive mushroom body neurons in insect olfactory learning

Watanabe, Hidehiro; Matsumoto, Chihiro Sato; Nishino, Hiroshi et al.

Neurobiology of Learning and Memory, 2011, 95(1), 1-13

Permalink : https://hdl.handle.net/2115/44990

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アクセス権
open access
URI
https://hdl.handle.net/2115/44990
タイトル
Critical roles of mecamylamine-sensitive mushroom body neurons in insect olfactory learning
著者
Watanabe, Hidehiro ; Matsumoto, Chihiro Sato ; Nishino, Hiroshi ; Mizunami, Makoto
著者名
Watanabe, Hidehiro
著者名
Matsumoto, Chihiro Sato
著者名
Nishino, Hiroshi
著者名
Mizunami, Makoto
言語
英語
キーワード
Acetylcholine
Olfactory learning
Mushroom bodies
Conditioned stimulus
Unconditioned stimulus
発行日
2011-01
出版者
Elsevier
収録物名
Neurobiology of Learning and Memory
巻(号)
95(1)
ページ
1-13
抄録
In insects, cholinergic neurons are thought to transmit olfactory conditioned stimulus (CS) to the sites for associating the CS with unconditioned stimulus (US), but the types of acetylcholine (ACh) receptor used by neurons participating in the association have not been determined. In cockroaches, a type of nicotinic ACh receptor specifically antagonized by mecamylamine (MEC) has been characterized. Here we investigated the roles of neurons possessing MEC-sensitive ACh receptors (MEC-sensitive neurons) in olfactory conditioning of salivation, monitored by changes in activities of salivary neurons, in cockroaches. Local and bilateral microinjection of MEC into each of the three olfactory centers, antennal lobes, calyces of the mushroom bodies and lateral protocerebra, impaired olfactory responses of salivary neurons, indicating that MEC-sensitive neurons in all olfactory centers participate in pathways mediating olfactory responses of salivary neurons. Conditioning of olfactory CS with sucrose US was impaired by injection of MEC into the antennal lobes or calyces, i.e., conditioned responses were absent even after recovery from MEC injection, suggesting that the CS-US association occurs in MEC-sensitive neurons in calyces (Kenyon cells) or in neurons in downstream pathways. In contrast, conditioned responses appeared after recovery from MEC injection into the lateral protocerebra, suggesting that MEC-sensitive neurons in the lateral protocerebra are downstream of the association sites. Since lateral protocerebra are major termination areas of mushroom body efferent neurons, we suggest that input synapses of MEC-sensitive Kenyon cells, or their output synapses upon mushroom body efferent neurons, are the sites for CS-US association for olfactory conditioning of salivation.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1074-7427
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.nlm.2010.10.004