Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: Possible involvement in ovulation

Fujimori, Chika; Ogiwara, Katsueki; Hagiwara, Akane; Rajapakse, Sanath; Kimura, Atsushi; Takahashi, Takayuki

Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: Possible involvement in ovulation

Fujimori, Chika; Ogiwara, Katsueki; Hagiwara, Akane et al.

Molecular and Cellular Endocrinology, 2011, 332(1-2), 67-77

Permalink : https://hdl.handle.net/2115/45012

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アクセス権	open access
URI	https://hdl.handle.net/2115/45012
タイトル	Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: Possible involvement in ovulation
著者	Fujimori, Chika ; Ogiwara, Katsueki ; Hagiwara, Akane ; Rajapakse, Sanath ; Kimura, Atsushi ; Takahashi, Takayuki
著者名 Fujimori, Chika
著者名 Ogiwara, Katsueki
著者名 Hagiwara, Akane
著者名 Rajapakse, Sanath
著者名 Kimura, Atsushi
著者名 Takahashi, Takayuki
言語	英語
キーワード	Prostaglandin E2
	Cyclooxygenase-2
	EP receptor
	Gene expression
	Ovulation
	Medaka
発行日	2011-01-30
出版者	Elsevier Ireland
収録物名	Molecular and Cellular Endocrinology
巻(号)	332(1-2)
ページ	67-77
抄録	In vitro ovulation of mature medaka ovarian follicles was inhibited by inhibitors of cyclooxygenase (COX) or by an antagonist of the prostaglandin E2 receptor (EP). Of the three medaka COX genes, ptgs2 was most dominantly expressed in the fish ovary. The ptgs2 transcript was detected in all sizes of growing follicles. In a 24-h spawning cycle, large-sized follicles contained ptgs2 mRNA at a fairly constant level. The levels of COX enzyme activity and prostaglandin E2 were also constant in the large-sized follicles during the spawning cycle. The expression of prostaglandin E2 receptor EP4b (ptger4b) mRNA was drastically upregulated in the large-sized follicles as the ovulation time approached. The current results indicate that prostaglandin E2. which might be produced by COX-2, is involved in the ovulation of medaka, and that EP4b is likely the receptor responsible for exerting the action of prostaglandin E2 in the process.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0303-7207
関連情報	PMID 20932877
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.mce.2010.09.015