Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis

Shigemura, Masahiko; Nasuhara, Yasuyuki; Konno, Satoshi; Hattori, Takeshi; Shimizu, Chikara; Matsuno, Kazuhiko; Nishimura, Masaharu

Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis

Shigemura, Masahiko; Nasuhara, Yasuyuki; Konno, Satoshi et al.

Lung, 2010, 188(2), 151-157

Permalink : https://hdl.handle.net/2115/45089

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アクセス権	open access
URI	https://hdl.handle.net/2115/45089
タイトル	Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis
著者	Shigemura, Masahiko ; Nasuhara, Yasuyuki ; Konno, Satoshi ; Hattori, Takeshi ; Shimizu, Chikara ; Matsuno, Kazuhiko ; Nishimura, Masaharu
著者名 Shigemura, Masahiko
著者名 Nasuhara, Yasuyuki
著者名 Konno, Satoshi
著者名 Hattori, Takeshi
著者名 Shimizu, Chikara
著者名 Matsuno, Kazuhiko
著者名 Nishimura, Masaharu
言語	英語
キーワード	Transferrin
	Bronchoalveolar lavage fluid
	Sarcoidosis
発行日	2010-04
出版者	Springer New York
収録物名	Lung
巻(号)	188(2)
ページ	151-157
抄録	There has been only one report showing high levels of transferrin (Tf) in bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis. The aim of this study is to assess the levels of Tf in both BALF and serum and to examine the relationship between the levels of Tf and other disease markers in sarcoidosis. Subjects were 64 sarcoidosis and 10 healthy controls. Tf in BALF and serum was measured by nephelometric assay. Median Tf levels in BALF from sarcoidosis was 0.70 mg/dl (range, 0.00-3.97), which was significantly higher when compared with controls (0.36 mg/dl; range, 0.00-1.02) (p = 0.005). In contrast, median Tf levels in serum from sarcoidosis was 258 mg/dl (range, 171-383), which was significantly lower when compared with controls (322 mg/dl; range, 234-356) (p = 0.003). Tf levels in BALF were significantly correlated with both the percentage of lymphocytes (r = 0.617, p = 0.001) and serum angiotensin-converting enzyme activity (r = 0.363, p = 0.003) and serum soluble interleukin-2 receptor (r = 0.450, p = 0.001) in sarcoidosis. Levels of Tf in BALF from patients with sarcoidosis were not influenced by smoking status. The levels of Tf in sarcoidosis are high in BALF, but low in serum. Increased levels of Tf in BALF may reflect the disease activity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0341-2040
関連情報	PMID 20066543
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00408-009-9218-7