open access

https://hdl.handle.net/2115/45092

Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice

英語

2010-04

Springer New York

Mammalian Genome

21(3-4)

162-171

MRL/MpJ (MRL) is a model mouse for autoimmune diseases that shows dermatitis, vasculitis, arthritis, and glomerulonephritis. In addition to these immune-associated disorders, we found that aged MRL mice develop ovarian cysts originating from the rete ovarii, which is lined by ciliated or nonciliated epithelium and considered remnants of mesonephric tubules. Ovarian cysts, which are reported to have several sources, are associated with female infertility, but information regarding the genetic etiology of ovarian cysts originating from the rete ovarii is rare. In this study, to elucidate the genetic background of development of ovarian cysts, we performed quantitative trait-locus (QTL) analysis using 120 microsatellite markers, which cover the whole genome of murine chromosomes, and 213 backcross progenies between female MRL and male C57BL/6N mice. The quantitative trait measured was the circumferences of rete ovarii or ovarian cysts. As a result, suggestive linkages were detected on Chr 3, 4, 6, and 11, but significant linkages were located on Chr 14 by interval mapping. We thereby designated the 27.5-cM region of Chr 14 "MRL Rete Ovarian Cysts (mroc)." The peak regions of Chr 4 and 14 in particular showed a close additive interaction (p < 0.00001). From these results, we concluded that multiple loci on Chr 3, 4, 6, 11, and 14 interact to result in development of ovarian cysts in MRL mice.

学術雑誌論文

Accepted Manuscript

The original publication is available at www.springerlink.com

0938-8990