An HDAC inhibitor increases AcMNPV gene expression in mammalian cells

Fujita, Ryosuke; Ohtsuka, Daisuke; Sahara, Ken; Asano, Shinichiro; Bando, Hisanori

An HDAC inhibitor increases AcMNPV gene expression in mammalian cells

Fujita, Ryosuke; Ohtsuka, Daisuke; Sahara, Ken et al.

Archives of Virology, 2010, 155(4), 577-581

Permalink : https://hdl.handle.net/2115/45094

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アクセス権	open access
URI	https://hdl.handle.net/2115/45094
タイトル	An HDAC inhibitor increases AcMNPV gene expression in mammalian cells
著者	Fujita, Ryosuke ; Ohtsuka, Daisuke ; Sahara, Ken ; Asano, Shinichiro ; Bando, Hisanori
著者名 Fujita, Ryosuke
著者名 Ohtsuka, Daisuke
著者名 Sahara, Ken
著者名 Asano, Shinichiro
著者名 Bando, Hisanori
言語	英語
キーワード	Baculovirus
	AcMNPV
	Histone deacetylation
	Nucleosome
	Epigenetic
	Gene therapy
発行日	2010-04
出版者	Springer Wien
収録物名	Archives of Virology
巻(号)	155(4)
ページ	577-581
抄録	The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is used as a safer viral vector in mammalian cells with potential applications in gene therapy. However, the mechanism for the insusceptibility of mammalian cells to proliferative infection by entomopathogenic viruses is not well understood. Here, we studied the significance of epigenetic modifications such as histone acetylation, histone methylation and HP1 accumulation to AcMNPV gene expression in mammalian BHK cells. Real-time PCR and chromatin immunoprecipitation with sodium butyrate revealed an important relationship between viral gene expression and histone acetylation, having implications for a mechanism of suppression of AcMNPV gene expression in BHK cells.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0304-8608
関連情報	PMID 20186445
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00705-010-0614-3