The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells

Hirata, Noriyuki; Yanagawa, Yoshiki; Ogura, Hisako; Satoh, Masashi; Noguchi, Masayuki; Matsumoto, Machiko; Togashi, Hiroko; Onoé, Kazunori; Iwabuchi, Kazuya

The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells

Hirata, Noriyuki; Yanagawa, Yoshiki; Ogura, Hisako et al.

Cellular Immunology, 2011, 266(2), 165-171

Permalink : https://hdl.handle.net/2115/45137

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/45137
タイトル	The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells
著者	Hirata, Noriyuki ; Yanagawa, Yoshiki ; Ogura, Hisako ; Satoh, Masashi ; Noguchi, Masayuki ; Matsumoto, Machiko ; Togashi, Hiroko ; Onoé, Kazunori ; Iwabuchi, Kazuya
著者名 Hirata, Noriyuki
著者名 Yanagawa, Yoshiki
著者名 Ogura, Hisako
著者名 Satoh, Masashi
著者名 Noguchi, Masayuki
著者名 Matsumoto, Machiko
著者名 Togashi, Hiroko
著者名 Onoé, Kazunori
著者名 Iwabuchi, Kazuya
言語	英語
キーワード	Dendritic cells
	Interleukin-10
	Signal transduction
	Tumor necrosis factor-α
	Toll-like receptor
発行日	2011
出版者	Elsevier
収録物名	Cellular Immunology
巻(号)	266(2)
ページ	165-171
抄録	In the present study, we examined the role of tumor necrosis factor (TNF) in interleukin (IL)-10 production by dendritic cells (DCs) using bone-marrow derived DCs from wild type (WT) and TNF-α knockout (TNF-α^[-/-]) mice. Toll-like receptor (TLR) stimulation induced substantial level of IL-10 production by WT DCs, but significantly low level of IL-10 production by TNF-α^[-/-] DCs. In contrast, no significant difference was detected in IL-12 p40 production between WT and TNF-α^[-/-] DCs. Addition of TNF-α during TLR stimulation recovered the impaired ability of TNF-α^[-/-] DCs for IL-10 production. This recovery appeared to be associated with an activation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and phosphatidylinositol 3-kinase/Akt following the TNF-α addition. Blocking these kinases significantly inhibited IL-10 production by TNF-α^[-/-] DCs stimulated with TLR ligands plus TNF-α. Thus, TNF-α may be a key molecule to regulate the balance between anti-inflammatory versus inflammatory cytokine production in DCs.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0008-8749
関連情報	PMID 20979991
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.cellimm.2010.09.012