A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells

Ishizuka, Satoshi; Saitoh, Ken-ichi; Suzuki, Takuya et al.

Food Chemistry, 2011, 125(4), 1219-1225

Permalink : https://hdl.handle.net/2115/45248

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アクセス権
open access
URI
https://hdl.handle.net/2115/45248
タイトル
A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells
著者
Ishizuka, Satoshi ; Saitoh, Ken-ichi ; Suzuki, Takuya ; Lee, Jae-Sung ; Hara, Hiroshi
著者名
Ishizuka, Satoshi
著者名
Saitoh, Ken-ichi
著者名
Suzuki, Takuya
著者名
Lee, Jae-Sung
著者名
Hara, Hiroshi
言語
英語
キーワード
Cell proliferation
5-bromo-2'-deoxyuridine
HCT116 cells
Phytate hydrolysate
発行日
2011-04-15
出版者
Elsevier
収録物名
Food Chemistry
巻(号)
125(4)
ページ
1219-1225
抄録
Phytate, myo-inositol hexaphosphate (IP6), has been shown to possess anti-carcinogenic qualities. IP6 appears to be partially digested in the digestive tract and degraded into inositol di, tri-, and tetra-phosphate (IP2, IP3, and IP4). The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH), a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line. IP3-RPH suppresses cell proliferation as well as IP6, and the suppression activity of IP3-RPH was higher than that of IP6. Suppression modes clearly differed between IP3-RPH and IP6. Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0308-8146
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.foodchem.2010.10.037