Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4

Togi, Sumihito; Ikeda, Sumihito; Kamitani, Sumihito; Nakasuji, Sumihito; Sekine, Sumihito; Muromoto, Ryuta; Nanbo, Asuka; Oritani, Kenji; Kawai, Taro; Akira, Shizuo; Matsuda, Tadashi

Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4

Togi, Sumihito; Ikeda, Sumihito; Kamitani, Sumihito et al.

Journal of Biological Chemistry, 2011, 286(21), 19170-19177

Permalink : https://hdl.handle.net/2115/45474

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アクセス権	open access
URI	https://hdl.handle.net/2115/45474
タイトル	Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4
著者	Togi, Sumihito ; Ikeda, Sumihito ; Kamitani, Sumihito ; Nakasuji, Sumihito ; Sekine, Sumihito ; Muromoto, Ryuta ; Nanbo, Asuka ; Oritani, Kenji ; Kawai, Taro ; Akira, Shizuo ; Matsuda, Tadashi
著者名 Togi, Sumihito
著者名 Ikeda, Sumihito
著者名 Kamitani, Sumihito
著者名 Nakasuji, Sumihito
著者名 Sekine, Sumihito
著者名 Muromoto, Ryuta
著者名 Nanbo, Asuka
著者名 Oritani, Kenji
著者名 Kawai, Taro
著者名 Akira, Shizuo
著者名 Matsuda, Tadashi
言語	英語
発行日	2011-05
出版者	American Society of Biochemistry and Molecular Biology
収録物名	Journal of Biological Chemistry
巻(号)	286(21)
ページ	19170-19177
抄録	Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in apoptosis and transcriptional regulation. Here, we identified Nemo-like kinase (NLK) as a novel ZIPK-binding partner, and found that ZIPK regulates NLK-mediated repression of canonical Wnt/β−catenin signaling. Indeed, siRNA-mediated reduction of endogenous ZIPK expression reduced Wnt/β−catenin signaling. Furthermore, ZIPK affected complex formation of NLK-T-cell factor (TCF) 4. Importantly, ZIPK siRNA treatment in human colon carcinoma cells resulted in a reduction of β−catenin/TCF-mediated gene expression and cell growth. These results indicate that ZIPK may serve as a transcriptional regulator of canonical Wnt/β−catenin signaling through interaction with NLK/TCF4.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Copyright ©2011 the American Society for Biochemistry and Molecular Biology
PISSN	0021-9258
EISSN	1083-351X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1074/jbc.M110.189829