Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma

Hayakawa, Mineji; Katabami, Kenichi; Wada, Takeshi; Minami, Yousuke; Sugano, Masahiro; Shimojima, Hidekazu; Kubota, Nobuhiko; Uegaki, Shinji; Sawamura, Atsushi; Gando, Satoshi

Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma

Hayakawa, Mineji; Katabami, Kenichi; Wada, Takeshi et al.

Inflammation, 2011, 34(3), 193-197

Permalink : https://hdl.handle.net/2115/45532

このアイテムのアクセス数:1,206件（2026-08-12 23:26 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
inflammation	pdf	247 KB	1,170

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/45532
タイトル	Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma
著者	Hayakawa, Mineji ; Katabami, Kenichi ; Wada, Takeshi ; Minami, Yousuke ; Sugano, Masahiro ; Shimojima, Hidekazu ; Kubota, Nobuhiko ; Uegaki, Shinji ; Sawamura, Atsushi ; Gando, Satoshi
e-Rad_Researcher 10374282 著者名 Hayakawa, Mineji
著者名 Katabami, Kenichi
e-Rad_Researcher 30455646 著者名 Wada, Takeshi
著者名 Minami, Yousuke
著者名 Sugano, Masahiro
著者名 Shimojima, Hidekazu
著者名 Kubota, Nobuhiko
著者名 Uegaki, Shinji
e-Rad_Researcher 00241448 著者名 Sawamura, Atsushi
著者名 Gando, Satoshi
言語	英語
キーワード	Glucocorticoids
	multiple organ failure
	multiple trauma
	tumor necrosis factor-alpha
	systemic inflammatory response syndrome
発行日	2011-06
出版者	Springer
収録物名	Inflammation
巻(号)	34(3)
ページ	193-197
抄録	Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the levels of MIF and cortisol in patients with blunt trauma. The cortisol levels were identical between the patients with and without MODS. However, the MIF and TNF-α levels in the patients with MODS were statistically higher than those of the patients without MODS. The cortisol/MIF ratios in the patients with MODS were statistically higher than those of the patients without MODS. The results show that MIF and TNF-α play an important role together in post-traumatic inflammatory response. An excessive serum MIF elevation overrides the anti-inflammatory effects of cortisol and leads to persistent SIRS followed by MODS in blunt trauma patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The originalpublication is available at www.springerlink.com
PISSN	0360-3997
EISSN	1573-2576
関連情報	PMID 20499270
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10753-010-9223-2