Stress Relaxation Measurement of Fibroblast Cells with Atomic Force Microscopy

Okajima, Takaharu; Tanaka, Masaru; Tsukiyama, Shusaku et al.

Japanese Journal of Applied Physics, 2007, 46(8B), 5552-5555

Permalink : https://hdl.handle.net/2115/45745

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/45745
タイトル
Stress Relaxation Measurement of Fibroblast Cells with Atomic Force Microscopy
著者
Okajima, Takaharu ; Tanaka, Masaru ; Tsukiyama, Shusaku ; Kadowaki, Tsubasa ; Yamamoto, Sadaaki ; Shimomura, Masatsugu ; Tokumoto, Hiroshi
e-Rad_Researcher
70280998
著者名
Okajima, Takaharu
著者名
Tanaka, Masaru
著者名
Tsukiyama, Shusaku
著者名
Kadowaki, Tsubasa
著者名
Yamamoto, Sadaaki
著者名
Shimomura, Masatsugu
e-Rad_Researcher
40357562
著者名
Tokumoto, Hiroshi
言語
英語
キーワード
Atomic force microscope
Living cells
Stress relaxation
Viscoelastic properties
Colloidal probe
発行日
2007-08
出版者
Japan Society of Applied Physics
収録物名
Japanese Journal of Applied Physics
巻(号)
46(8B)
ページ
5552-5555
抄録
We measured the stress relaxation of mouse fibroblast NIH3T3 cells with an atomic force microscope (AFM) using a sharp silicon tip and a silica bead with a radius of ∼1 µm as an indenter. The decay of loading force was clearly observed in NIH3T3 cells at a small initial loading force of ∼0.4 nN and was well fitted to the stretched exponential function rather than to a single exponential function. The stretching exponent parameter was ∼0.5 for both indenters, indicating that the stress relaxation observed in NIH3T3 cells consisted of multiple relaxation processes. The time-domain AFM technique described in this report allows us to measure directly the relaxation process of living cells in a range from milliseconds to seconds.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0021-4922
NCID
AA12295836
関連情報
URI
http://jjap.jsap.jp/link?JJAP/46/5552/
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1143/JJAP.46.5552