Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy

Hiratsuka, Shinichiro; Mizutani, Yusuke; Toda, Akitoshi; Fukushima, Norichika; Kawahara, Koichi; Tokumoto, Hiroshi; Okajima, Takaharu

Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy

Hiratsuka, Shinichiro; Mizutani, Yusuke; Toda, Akitoshi et al.

Japanese Journal of Applied Physics, 2009, 48(8), 08JB17

Permalink : https://hdl.handle.net/2115/45747

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アクセス権	open access
URI	https://hdl.handle.net/2115/45747
タイトル	Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy
著者	Hiratsuka, Shinichiro ; Mizutani, Yusuke ; Toda, Akitoshi ; Fukushima, Norichika ; Kawahara, Koichi ; Tokumoto, Hiroshi ; Okajima, Takaharu
著者名 Hiratsuka, Shinichiro
著者名 Mizutani, Yusuke
著者名 Toda, Akitoshi
著者名 Fukushima, Norichika
著者名 Kawahara, Koichi
e-Rad_Researcher 40357562 著者名 Tokumoto, Hiroshi
e-Rad_Researcher 70280998 著者名 Okajima, Takaharu
言語	英語
発行日	2009-08
出版者	Japan Society of Applied Physics
収録物名	Japanese Journal of Applied Physics
巻(号)	48(8)
ページ	08JB17
抄録	We measured stress and creep relaxations of mouse fibroblast cells arranged and cultured on a microarray, by colloidal probe atomic force microscopy (AFM). A hydrophobic monolayer coating of perfluorodecyltrichlorosilane (FDTS) on the surface of colloidal silica beads significantly reduced the adhesion force of live cells, compared with untreated beads. The rheological behaviors of cells were estimated by averaging several relaxation curves of cells measured by the AFM. Longer-time tailing of both stress and creep relaxation curves followed single power-law behavior over a time scale of 60 s, with exponents in the range 0.1–0.4, varying with cells. The results were in good agreement with previous measurements of the frequency-domain rheology of cells using the force modulation mode.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0021-4922
EISSN	1347-4065
NCID	AA12295836
関連情報	URI http://jjap.jsap.jp/link?JJAP/48/08JB17/
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1143/JJAP.48.08JB17