Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy

Hiratsuka, Shinichiro; Mizutani, Yusuke; Toda, Akitoshi et al.

Japanese Journal of Applied Physics, 2009, 48(8), 08JB17

Permalink : https://hdl.handle.net/2115/45747

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アクセス権
open access
URI
https://hdl.handle.net/2115/45747
タイトル
Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy
著者
Hiratsuka, Shinichiro ; Mizutani, Yusuke ; Toda, Akitoshi ; Fukushima, Norichika ; Kawahara, Koichi ; Tokumoto, Hiroshi ; Okajima, Takaharu
著者名
Hiratsuka, Shinichiro
著者名
Mizutani, Yusuke
著者名
Toda, Akitoshi
著者名
Fukushima, Norichika
著者名
Kawahara, Koichi
e-Rad_Researcher
40357562
著者名
Tokumoto, Hiroshi
e-Rad_Researcher
70280998
著者名
Okajima, Takaharu
言語
英語
発行日
2009-08
出版者
Japan Society of Applied Physics
収録物名
Japanese Journal of Applied Physics
巻(号)
48(8)
ページ
08JB17
抄録
We measured stress and creep relaxations of mouse fibroblast cells arranged and cultured on a microarray, by colloidal probe atomic force microscopy (AFM). A hydrophobic monolayer coating of perfluorodecyltrichlorosilane (FDTS) on the surface of colloidal silica beads significantly reduced the adhesion force of live cells, compared with untreated beads. The rheological behaviors of cells were estimated by averaging several relaxation curves of cells measured by the AFM. Longer-time tailing of both stress and creep relaxation curves followed single power-law behavior over a time scale of 60 s, with exponents in the range 0.1–0.4, varying with cells. The results were in good agreement with previous measurements of the frequency-domain rheology of cells using the force modulation mode.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0021-4922
EISSN
1347-4065
NCID
AA12295836
関連情報
URI
http://jjap.jsap.jp/link?JJAP/48/08JB17/
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1143/JJAP.48.08JB17