Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens

Sasaki, Nobuo; Matsumoto, Tomoyuki; Ikenaka, Yoshinori; Kazusaka, Akio; Ishizuka, Mayumi; Fujita, Shoichi

Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens

Sasaki, Nobuo; Matsumoto, Tomoyuki; Ikenaka, Yoshinori et al.

Pesticide Biochemistry and Physiology, 2011, 100(2), 135-139

Permalink : https://hdl.handle.net/2115/45809

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アクセス権	open access
URI	https://hdl.handle.net/2115/45809
タイトル	Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens
著者	Sasaki, Nobuo ; Matsumoto, Tomoyuki ; Ikenaka, Yoshinori ; Kazusaka, Akio ; Ishizuka, Mayumi ; Fujita, Shoichi
著者名 Sasaki, Nobuo
著者名 Matsumoto, Tomoyuki
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 00002113 著者名 Kazusaka, Akio
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
e-Rad_Researcher 10143314 著者名 Fujita, Shoichi
言語	英語
キーワード	Chicken
	Cytochrome P450
	Furazolidone
	Liver
	NADPH cytochrome P450 reductase
発行日	2011-06
出版者	Elsevier
収録物名	Pesticide Biochemistry and Physiology
巻(号)	100(2)
ページ	135-139
抄録	The nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to identify the enzyme that contributes to FZ metabolism in chickens. Wistar rats and White Leghorn chickens were administered FZ once a day for 4 consecutive days. FZ metabolism was accelerated by FZ administration in chickens, but not in rats. The elevation of FZ metabolism coincided with the induction of NADPH cytochrome P450 reductase (CPR) activity in chickens, but such induction was not observed in rats. FZ metabolizing activities were inhibited in the presence of a CPR inhibitor (diphenylene iodonium chloride) but not by the addition of archetypal cytochrome P450 inhibitors (CO or n-octylamine). The preset study concluded that FZ accelerated its own metabolism in the chicken by induction of the activity of CPR.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0048-3575
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.pestbp.2011.02.013