Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET

Wu, Yen-Wen; Naya, Masanao; Tsukamoto, Takahiro; Komatsu, Hiroshi; Morita, Koichi; Yoshinaga, Keiichiro; Kuge, Yuji; Tsutsui, Hiroyuki; Tamaki, Nagara

Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET

Wu, Yen-Wen; Naya, Masanao; Tsukamoto, Takahiro et al.

Circulation Journal, 2008, 72(5), 786-792

Permalink : https://hdl.handle.net/2115/45964

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アクセス権	open access
URI	https://hdl.handle.net/2115/45964
タイトル	Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET
著者	Wu, Yen-Wen ; Naya, Masanao ; Tsukamoto, Takahiro ; Komatsu, Hiroshi ; Morita, Koichi ; Yoshinaga, Keiichiro ; Kuge, Yuji ; Tsutsui, Hiroyuki ; Tamaki, Nagara
著者名 Wu, Yen-Wen
著者名 Naya, Masanao
著者名 Tsukamoto, Takahiro
著者名 Komatsu, Hiroshi
著者名 Morita, Koichi
著者名 Yoshinaga, Keiichiro
著者名 Kuge, Yuji
著者名 Tsutsui, Hiroyuki
著者名 Tamaki, Nagara
言語	英語
キーワード	Carbon-11 acetate PET
	Dilated cardiomyopathy
	Ischemic cardiomyopathy
	Left ventricular dysfunction
	Myocardial oxidative metabolism
発行日	2008
出版者	日本循環器学会
収録物名	Circulation Journal
巻(号)	72(5)
ページ	786-792
抄録	Background :The 11C-acetate positron emission tomography can estimate myocardial oxidative metabolism, but previous studies have only evaluated small populations and the difference between ischemic (ICM) and idiopathic dilated cardiomyopathy (DCM) has not been fully investigated. The present aims were to evaluate global and regional myocardial oxidative metabolism in a well-characterized, large population with left ventricular (LV) dysfunction in order to clarify the metabolic differences between ICM and DCM. Methods and Results :Seventy-eight patients with ejection fraction (EF) ≤50% (33 ICM; 45 DCM) were compared with 14 healthy controls. Myocardial oxidative metabolism was estimated with a clearance rate constant (Kmono) and the coefficient of variation (CV) of regional Kmono. Patients with LV dysfunction had reduced Kmono and higher CV (p<0.05). In the comparison of oxidative alterations with clinical variables there was a weak correlation between Kmono and LVEF (r=0.27). Although Kmono was reduced in both ICM and DCM, CV was more pronouncedly increased in ICM (p=0.001). In multivariate analysis, the presence of left bundle branch block (LBBB) was an independent predictor of heterogeneous oxidative metabolism in DCM (R2=0.30, p<0.0001). Conclusions :Global reduction of myocardial oxidative metabolism occurred in both ICM and DCM. Heterogeneous oxidative metabolism was observed in these patients, especially those with ICM. Furthermore, LBBB was the independent predictor of heterogeneous oxidative metabolism in patients with DCM. (Circ J 2008; 72: 786 - 792)
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1346-9843
EISSN	1347-4820
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1253/circj.72.786