Myocardial  beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy

Naya, Masanao; Tsukamoto, Takahiro; Morita, Koichi; Katoh, Chietsugu; Nishijima, Kenichi; Komatsu, Hiroshi; Yamada, Satoshi; Kuge, Yuji; Tamaki, Nagara; Tsutsui, Hiroyuki

Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy

Naya, Masanao; Tsukamoto, Takahiro; Morita, Koichi et al.

Journal of Nuclear Medicine, 2009, 50(2), 220-225

Permalink : https://hdl.handle.net/2115/46754

このアイテムのアクセス数:1,268件（2026-08-09 05:28 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
50_2_220	pdf	479 KB	967

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/46754
タイトル	Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy
著者	Naya, Masanao ; Tsukamoto, Takahiro ; Morita, Koichi ; Katoh, Chietsugu ; Nishijima, Kenichi ; Komatsu, Hiroshi ; Yamada, Satoshi ; Kuge, Yuji ; Tamaki, Nagara ; Tsutsui, Hiroyuki
著者名 Naya, Masanao
著者名 Tsukamoto, Takahiro
著者名 Morita, Koichi
著者名 Katoh, Chietsugu
著者名 Nishijima, Kenichi
著者名 Komatsu, Hiroshi
著者名 Yamada, Satoshi
著者名 Kuge, Yuji
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
著者名 Tsutsui, Hiroyuki
言語	英語
キーワード	b-adrenergic receptor
	carvedilol
	11C-CGP12177PET
	heart failure
発行日	2009
出版者	Society of Nuclear Medicine
収録物名	Journal of Nuclear Medicine
巻(号)	50(2)
ページ	220-225
抄録	We evaluated whether myocardial b-adrenergic receptor (b-AR) density, as determined by 11C-CGP12177 PET, could predict improvement of cardiac function by b-blocker carvedilol treatment in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Ten patients with IDC (left ventricular ejection fraction [LVEF] , 45%) were studied. Myocardial b-AR density was estimated using 11C-CGP12177 PET before treatment with carvedilol. Changes of LVEF in response to dobutamine infusion (DLVEF-dobutamine) were also measured by echocardiography. Changes of LVEF (DLVEF-carvedilol) were evaluated after 20 mo of carvedilol treatment. Results: Baseline myocardial b-AR density significantly correlated with DLVEF-carvedilol (r 5 20.88, P , 0.001). In contrast, DLVEF-dobutamine did not correlate with DLVEF-carvedilol (P50.65).Myocardial b-ARdensitywas the significant multivariate independent predictor of DLVEF-carvedilol (b 5 20.88, P , 0.001) among univariate predictors, including functional class (r 5 0.76, P , 0.05), plasma norepinephrine (r 5 0.85, P,0.01), LVEF (r520.64, P,0.05), and age as confounding factors. Furthermore, myocardial b-AR density was significantly correlated with plasma norepinephrine (r 5 20.79, P , 0.01) and LVEF (r 5 0.70, P , 0.05). Conclusion: Myocardial b-AR density is more tightly related to improvement of LVEFcarvedilol than is cardiac contractile reserve in patients with IDC. Patients with decreased myocardial b-AR have higher resting adrenergic drive, as reflected by plasma norepinephrine, and may receive greater benefit from being treated by antiadrenergic drugs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Reprinted by permission of the Society of Nuclear Medicine
PISSN	0161-5505
関連情報	PMID 19164238
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2967/jnumed.108.056341