open access

https://hdl.handle.net/2115/46758

Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1

英語

MRL congenic mouse

2010-07

SAGE Publications

Lupus

19(8)

897-905

B6.MRLc1(82-100) congenic mice carrying the telomeric region of lupus-prone MRL chromosome 1 develop autoimmune glomerulonephritis (GN). The GN susceptibility locus of B6.MRLc1(82-100) contains the interferon activated gene 200 (Ifi200) family, which consists of Ifi202, 203, 204, and 205. Recently, Ifi202 was suggested as a candidate gene for murine lupus. In this study, we assessed the association between Ifi200 family and GN in several disease models. We compared the expression of Ifi200 family members in 24 organs between the C57BL/6 and B6.MRLc1(82-100). The expressions of Ifi200 family members differed between strains, especially, the most dramatic differences appeared in Ifi202 expression. Briefly, in the blood, immune organs, lungs, and testes was higher in B6.MRLc1(82-100) mice. In the kidney and immune organs, only Ifi202 expression increased with the development of GN in B6.MRLc1(82-100), and significant differences from C57BL/6 were observed even before disease onset. Ifi202 expression in the kidneys of BXSB, NZB/WF1, and MRL/lpr was also significantly high in the early- and late-disease stages. Furthermore, laser microdissection-RT-PCR analysis confirmed the high Ifi202 expression in all areas of B6.MRLc1(82-100) kidneys. In conclusion, among Ifi200 family, Ifi202 expressions in the kidney and immune organs significantly increased with GN progression.

学術雑誌論文

Accepted Manuscript

The final, definitive version of this article has been published in the Journal, Lupus, 19(8), 2010 of publication, © SAGE Publications Ltd, 2010 by SAGE Publications Ltd at the Lupus page: http://lup.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/

0961-2033