TRIM29 negatively regulates p53 via inhibition of Tip60

Sho, Takuya; Tsukiyama, Tadasuke; Sato, Tomonobu; Kondo, Takeshi; Cheng, Jun; Saku, Takashi; Asaka, Masahiro; Hatakeyama, Shigetsugu

TRIM29 negatively regulates p53 via inhibition of Tip60

Sho, Takuya; Tsukiyama, Tadasuke; Sato, Tomonobu et al.

Biochimica et Biophysica Acta (BBA) : Molecular Cell Research, 2011, 1813(6), 1245-1253

Permalink : https://hdl.handle.net/2115/46880

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アクセス権	open access
URI	https://hdl.handle.net/2115/46880
タイトル	TRIM29 negatively regulates p53 via inhibition of Tip60
著者	Sho, Takuya ; Tsukiyama, Tadasuke ; Sato, Tomonobu ; Kondo, Takeshi ; Cheng, Jun ; Saku, Takashi ; Asaka, Masahiro ; Hatakeyama, Shigetsugu
著者名 Sho, Takuya
著者名 Tsukiyama, Tadasuke
著者名 Sato, Tomonobu
著者名 Kondo, Takeshi
著者名 Cheng, Jun
著者名 Saku, Takashi
著者名 Asaka, Masahiro
著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	TRIM29
	p53
	Tip60
	Ubiquitin
	Ataxia-telangiectasia
発行日	2011-06
出版者	Elsevier B.V.
収録物名	Biochimica et Biophysica Acta (BBA) : Molecular Cell Research
巻(号)	1813(6)
ページ	1245-1253
抄録	Ataxia-telangiectasia (AT) is an autosomal recessive genetic disease characterized by immunological deficiencies, neurological degeneration, developmental abnormalities and an increased risk of cancer. Ataxia-telangiectasia group D (ATDC) was initially described as a gene related to AT. ATDC, also known as TRIM29, is structurally a member of the tripartite motif (TRIM) family of proteins, some of which have been reported to be highly expressed in some human carcinomas, but the involvement of TRIM29 in carcinogenesis has not been fully elucidated. In this study, we found by using yeast two-hybrid screening that TRIM29 binds to Tip60, which has been reported as a cellular acetyltransferase protein. Overexpression of TRIM29 promoted degradation and changed localization of Tip60 and reduced acetylation of p53 at lysine 120 by Tip60, resulting in enhancement of cell growth and transforming activity. In addition, we found that TRIM29 suppresses apoptosis induced by UV irradiation in HCT116 cell lines. These findings suggest that TRIM29 functions as an oncogene that promotes tumor growth.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0167-4889
関連情報	PMID 21463657
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbamcr.2011.03.018