High Prevalence of Multiple Human Papillomavirus Infection in Japanese Patients with Invasive Uterine Cervical Cancer

Watari, Hidemichi; Michimata, Rie; Yasuda, Motoaki; Ishizu, Akihiro; Tomaru, Utano; Xiong, Ying; Hassan, Mohamed K.; Sakuragi, Noriaki

High Prevalence of Multiple Human Papillomavirus Infection in Japanese Patients with Invasive Uterine Cervical Cancer

Watari, Hidemichi; Michimata, Rie; Yasuda, Motoaki et al.

Pathobiology, 2011, 78(4), 220-226

Permalink : https://hdl.handle.net/2115/46895

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/46895
タイトル	High Prevalence of Multiple Human Papillomavirus Infection in Japanese Patients with Invasive Uterine Cervical Cancer
著者	Watari, Hidemichi ; Michimata, Rie ; Yasuda, Motoaki ; Ishizu, Akihiro ; Tomaru, Utano ; Xiong, Ying ; Hassan, Mohamed K. ; Sakuragi, Noriaki
著者名 Watari, Hidemichi
著者名 Michimata, Rie
e-Rad_Researcher 90239765 著者名 Yasuda, Motoaki
e-Rad_Researcher 60321957 著者名 Ishizu, Akihiro
e-Rad_Researcher 20360901 著者名 Tomaru, Utano
著者名 Xiong, Ying
著者名 Hassan, Mohamed K.
e-Rad_Researcher 70153963 著者名 Sakuragi, Noriaki
言語	英語
キーワード	Human papillomavirus, multiple infection
	Cervix uteri
	Array technology
発行日	2011-07
出版者	Karger
収録物名	Pathobiology
巻(号)	78(4)
ページ	220-226
抄録	Objective: Multiple human papillomavirus (HPV) infection of the uterine cervix has been suggested as a risk factor for persistent HPV infection, resulting in the development of invasive cervical cancer. The aim of this study was to reveal the actual state of multiple HPV infection in Japanese patients with invasive cervical cancer. Methods: Freshly-frozen 60 invasive cervical cancer tissues were examined for genotyping of HPV. The presence of HPV genotypes in the cancer tissues was determined by an HPV-DNA array, which can discriminate 25 different HPV genotypes with high sensitivity and specificity. Results: Among 60 samples, 59 (96.7%) were positive for HPV. The three common genotypes were HPV-16 (83.3%), HPV-18 (45.0%) and HPV-52 (28.3%). Multiple HPV infection was observed in 47 of 60 samples (78.3%), in which 42 cases were infected with more than one high-risk genotypes (70.0%). The multiple high-risk HPV infection was significantly more prevalent in patients below 40 years old (14/15, 93.3%) than in patients 40 years and over (28/45, 62.2%). Conclusion: The HPV-DNA array is the preferable method to detect HPV genotypes. Multiple HPV infection in Japanese patients with invasive cervical cancer seemed to be more frequent than reported in the literature.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Copyright © 2011 S. Karger AG, Basel
PISSN	1015-2008
関連情報	PMID 21778789
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1159/000326770