2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside

Matsuda, Akira; Ohara, Yoshiko; Kakutani, Toshifumi; Negishi, Kazuo; Wataya, Yusuke; Hayatsu, Hikoya; Ueda, Tohru

2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside

Matsuda, Akira; Ohara, Yoshiko; Kakutani, Toshifumi et al.

Nucleic Acids Research, 1990, 18(7), 1833-1838

Permalink : https://hdl.handle.net/2115/46969

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アクセス権	open access
URI	https://hdl.handle.net/2115/46969
タイトル	2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside
著者	Matsuda, Akira ; Ohara, Yoshiko ; Kakutani, Toshifumi ; Negishi, Kazuo ; Wataya, Yusuke ; Hayatsu, Hikoya ; Ueda, Tohru
著者名 Matsuda, Akira
著者名 Ohara, Yoshiko
著者名 Kakutani, Toshifumi
著者名 Negishi, Kazuo
著者名 Wataya, Yusuke
著者名 Hayatsu, Hikoya
著者名 Ueda, Tohru
言語	英語
発行日	1990-04
出版者	Oxford University Press
収録物名	Nucleic Acids Research
巻(号)	18(7)
ページ	1833-1838
抄録	A crude preparation of 2-phenyladenosine was found to be mutagenlc in the Ames Salmonella assay. In the purification of this preparation, it was revealed that 2-phenyladenosine itself was nonmutagenic but that 2-(m- and p-nitrophenyl)-adenosines (5m,p) contaminating the sample were the mutagenic principles. A structure-activity relationship study was carried out, and it was found that 5p, 2-(p-nitrophenyl)- adenine (7p), and 2-(p-nitrophenyl)-2′-deoxyadenosine (15p) were strongly mutagenic toward S. typhimurium TA98 and TA100 without metabolic activation, the potency being in the order 15p > 7p > 5p. The potency of 15p in TA98 was one order of magnitude greater than that of 4-nitroquinoline N-oxide. 15p also showed mutagenicity in the mouse cell line FM3A in culture.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0305-1048
EISSN	1362-4962
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1093/nar/18.7.1833