Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models

Kimura, T.; Sasaki, M.; Okumura, M.; Kim, E.; Sawa, H.

Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models

Kimura, T.; Sasaki, M.; Okumura, M. et al.

Veterinary Pathology, 2010, 47(5), 806-818

Permalink : https://hdl.handle.net/2115/47038

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アクセス権	open access
URI	https://hdl.handle.net/2115/47038
タイトル	Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models
著者	Kimura, T. ; Sasaki, M. ; Okumura, M. ; Kim, E. ; Sawa, H.
e-Rad_Researcher 90261338 著者名 Kimura, T.
著者名 Sasaki, M.
著者名 Okumura, M.
著者名 Kim, E.
著者名 Sawa, H.
言語	英語
キーワード	experimental animal models
	Flavivirus
	histopathology
	Japanese encephalitis virus
	mice
	mosquito-borne encephalitis
	West Nile virus
発行日	2010-09
出版者	Sage Publications
収録物名	Veterinary Pathology
巻(号)	47(5)
ページ	806-818
抄録	Encephalitic flaviviruses are important arthropod-borne pathogens of humans and other animals. In particular, the recent emergence of the West Nile virus (WNV) and Japanese encephalitis virus (JEV) in new geographic areas has caused a considerable public health alert and international concern. Among the experimental in vivo models of WNV and JEV infection, mice and other laboratory rodents are the most thoroughly studied and well-characterized systems, having provided data that are important for understanding the infectious process in humans. Macaca monkeys have also been used as a model for WNV and JEV infection, mainly for the evaluation of vaccine efficacy, whereas a limited number of published studies address pathomorphology. These animal models develop encephalitis with many similarities to the human disease; however, the histological events that occur during infection, especially in peripheral tissues, have not been fully characterized.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final, definitive version of this article has been published in the Journal, Veterinary Pathology, 47/5, 2010 of publication, © American College of Veterinary Pathologists, 2010 by SAGE Publications Ltd at the Veterinary Pathology page: http://vet.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/
PISSN	0300-9858
関連情報	PMID 20551474
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1177/0300985810372507