Electron track analysis for damage formation in bio-cells

Yoshii, Y.; Sutherland, K. L.; Date, H.

Nuclear Instruments and Methods in Physics Research Section B : Beam Interactions with Materials and Atoms, 2011, 269(17), 1887-1891

Permalink : https://hdl.handle.net/2115/47045

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アクセス権
open access
URI
https://hdl.handle.net/2115/47045
タイトル
Electron track analysis for damage formation in bio-cells
著者
Yoshii, Y. ; Sutherland, K. L. ; Date, H.
著者名
Yoshii, Y.
著者名
Sutherland, K. L.
e-Rad_Researcher
10197600
著者名
Date, H.
言語
英語
キーワード
Electron track
Monte Carlo simulation
Aggregation index
Ionization cluster
発行日
2011-09-01
出版者
Elsevier B.V.
収録物名
Nuclear Instruments and Methods in Physics Research Section B : Beam Interactions with Materials and Atoms
巻(号)
269(17)
ページ
1887-1891
抄録
The track structure of electrons generated in bio-tissues exposed to X-rays (or other radiation particles) is essential to cell damage. This paper reports on Monte Carlo track simulations of electrons to determine the degree of concentration of ionization and excitation events as the aggregation index (AI). AI is expected to correlate with the number of lesions in a cell nucleus, such as double-strand breaks (DSBs), which may lead to lethality of cells. The simulation results show that AI as a function of electron energy has a peak in low energy (sub-keV) regions and the induction of the lesions may be attributed to the ionization and excitation clusters generated in the tissues. The track pattern, associated with the primary track and secondary branch tracks, is also illustrated by counting the number of the branching points given by the ionization.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0168-583X
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.nimb.2011.05.028