Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus

Chen, Jiancheng; Yamada, Shuhei; Hama, Yoshiki et al.

Biochemical and Biophysical Research Communications, 2011, 412(1), 136-142

Permalink : https://hdl.handle.net/2115/47200

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アクセス権
open access
URI
https://hdl.handle.net/2115/47200
タイトル
Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus
著者
Chen, Jiancheng ; Yamada, Shuhei ; Hama, Yoshiki ; Shetty, Ajaya Kumar ; Kobayashi, Takanari ; Oda, Hiroshi ; Seiki, Kosuke ; Kim, Eunmi ; Kimura, Takashi ; Takahashi, Naonori ; Hidari, Kazuya I. P. J. ; Suzuki, Takashi ; Suzuki, Yasuo ; Sugahara, Kazuyuki
著者名
Chen, Jiancheng
e-Rad_Researcher
70240017
著者名
Yamada, Shuhei
著者名
Hama, Yoshiki
著者名
Shetty, Ajaya Kumar
著者名
Kobayashi, Takanari
著者名
Oda, Hiroshi
著者名
Seiki, Kosuke
著者名
Kim, Eunmi
著者名
Kimura, Takashi
著者名
Takahashi, Naonori
著者名
Hidari, Kazuya I. P. J.
著者名
Suzuki, Takashi
著者名
Suzuki, Yasuo
著者名
Sugahara, Kazuyuki
言語
英語
キーワード
Glycosaminoglycans
Heparan sulfate
Dengue virus
Japanese encephalitis virus
Anticoagulant activity
発行日
2011-08-19
出版者
Elsevier
収録物名
Biochemical and Biophysical Research Communications
巻(号)
412(1)
ページ
136-142
抄録
The structure and biological activities of a highly sulfated heparan sulfate (HS) extracted from shrimp (Penaeus brasiliensis) heads were characterized. Structurally the shrimp HS was more heterogenous than heparin, although it is still highly sulfated. The molecular mass of the shrimp HS preparation was determined to be 32.3 kDa by gel filtration HPLC. Analysis by surface plasmon resonance demonstrated that various growth/differentiation factors specifically bound to the shrimp HS with comparable affinity. Notably, the shrimp HS had a greater inhibitory effect against infections by dengue virus type 2 as well as Japanese encephalitis virus than heparin. Experiments on anticoagulant activity indicated that the shrimp HS exhibited significant anti-thrombin activity, but less than the commercial heparin. Hence, the HS preparation from shrimp heads, an industrial waste, is a prospective agent for a variety of clinical applications.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0006-291X
関連情報
PMID
21806963
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbrc.2011.07.059