Assessing the roles of presynaptic ryanodine receptors and adenosine receptors in caffeine-induced enhancement of hippocampal mossy fiber transmission

Sato, Ikuma; Kamiya, Haruyuki

Neuroscience Research, 2011, 71(2), 183-187

Permalink : https://hdl.handle.net/2115/47363

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アクセス権	open access
URI	https://hdl.handle.net/2115/47363
タイトル	Assessing the roles of presynaptic ryanodine receptors and adenosine receptors in caffeine-induced enhancement of hippocampal mossy fiber transmission
著者	著者名 Sato, Ikuma
著者	e-Rad_Researcher 10194979 著者名 Kamiya, Haruyuki
言語	英語
キーワード	Hippocampus
	Mossy fiber
	Caffeine
	Ryanodine receptor
	Presynapse
	Ca2+ store
発行日	2011-10
出版者	Elsevier Ireland
収録物名	Neuroscience Research
巻(号)	71(2)
ページ	183-187
抄録	Caffeine robustly enhances transmitter release from the hippocampal mossy fiber terminals, although it remains uncertain whether calcium mobilization through presynaptic ryanodine receptors mediates this enhancement. In this study, we adopted a selective adenosine A1 blocker to assess relative contribution of A1 receptors and ryanodine receptors in caffeine-induced synaptic enhancement. Application of caffeine further enhanced transmission at the hippocampal mossy fiber synapse even after full blockade of adenosine A1 receptors. This result suggests that caffeine enhances mossy fiber synaptic transmission by two distinct presynaptic mechanisms, i.e., removal of A1 receptor-mediated tonic inhibition and ryanodine receptor-mediated calcium release from intracellular stores.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0168-0102
関連情報	PMID 21782858
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.neures.2011.07.001