Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts

Sanada, Takahiro; Kariwa, Hiroaki; Nagata, Noriyo; Tanikawa, Yoichi; Seto, Takahiro; Yoshimatsu, Kumiko; Arikawa, Jiro; Yoshii, Kentaro; Takashima, Ikuo

Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts

Sanada, Takahiro; Kariwa, Hiroaki; Nagata, Noriyo et al.

Virus Research, 2011, 160(1-2), 108-119

Permalink : https://hdl.handle.net/2115/47378

このアイテムのアクセス数:1,549件（2026-05-15 05:45 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
VR160-1-2_108-119	pdf	976 KB	1,199

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/47378
タイトル	Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts
著者	Sanada, Takahiro ; Kariwa, Hiroaki ; Nagata, Noriyo ; Tanikawa, Yoichi ; Seto, Takahiro ; Yoshimatsu, Kumiko ; Arikawa, Jiro ; Yoshii, Kentaro ; Takashima, Ikuo
著者名 Sanada, Takahiro
e-Rad_Researcher 70224714 著者名 Kariwa, Hiroaki
e-Rad_Researcher 30270648 著者名 Nagata, Noriyo
著者名 Tanikawa, Yoichi
著者名 Seto, Takahiro
著者名 Yoshimatsu, Kumiko
e-Rad_Researcher 10142704 著者名 Arikawa, Jiro
e-Rad_Researcher 50421988 著者名 Yoshii, Kentaro
e-Rad_Researcher 30002083 著者名 Takashima, Ikuo
言語	英語
キーワード	Hantavirus
	Puumala virus
	Animal model
	Persistent infection
	Hamster
発行日	2011-09
出版者	Elsevier B.V.
収録物名	Virus Research
巻(号)	160(1-2)
ページ	108-119
抄録	The mechanism of hantavirus persistent infection in natural hosts is poorly understood due to a lack of laboratory animal models. Herein, we report that Syrian hamsters (Mesocricetus auratus) infected with Puumala virus (PUUV) at 4 weeks old show persistent infection without clinical symptoms for more than 2 months. IgG and IgM antibodies against the viral nucleocapsid protein and neutralizing antibody were first detectable at 14 days postinoculation (dpi) and maintained through 70 dpi. Viral RNA was first detected from 3 dpi in lungs and blood clots, and was detected in all tissues tested at 7 dpi. The viral RNA persisted for at least 70 days in the lungs, kidney, spleen, heart, and brain. The highest level of RNA copies was observed at 14 dpi in the lungs. Slight inflammatory reactions were observed in the lungs, adrenal glands, and brain. Immunohistochemical analysis revealed that PUUV antigen persisted until 56 dpi in the kidneys and adrenal glands. Infected hamsters showed no body weight loss or clinical signs. These results indicate that PUUV infection in hamsters is quite similar to the hantavirus infection of natural host rodents.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0168-1702
関連情報	PMID 21672562
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.virusres.2011.05.021