open access

https://hdl.handle.net/2115/47396

Effects of γ-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells

英語

Bcl-2 family

2008-08

Taylor & Francis

Journal of Environmental Science and Health, Part B : Pesticides, Food Contaminants, & Agricultural Wastes

43(6)

471-475

The effects of γ-hexachlorocyclohexane, one of the endocrine disrupters, widely used for agricultural and medicinal purpose, on apoptosis in PC12 cells were investigated using western blotting analysis and reverse transcriptase-DNA polymerase chain reaction (RT-PCR) method. Apoptosis is a fundamental process necessary for development of individuals and organs. Although γ -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of γ-HCH to the cell medium. However these changes were not statistically significant. It was concluded that γ -HCH did not affect on apoptosis in the PC12 cell line system, although γ -HCH has been reported to induce apoptosis in other cell lines.

学術雑誌論文

Accepted Manuscript

This is a preprint of an article submitted for consideration in the Journal of Environmental Science and Health, Part B © 2008 Taylor & Francis. Journal of Environmental Science and Health, Part B is available online at: www.tandfonline.com.

0360-1234

1532-4109

AA00697424