Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

Seki, Sayaka; Aoki, Miho; Hosokawa, Toshiyuki; Saito, Takeshi; Masuma, Runa; Komori, Miyako; Kurasaki, Masaaki

Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

Seki, Sayaka; Aoki, Miho; Hosokawa, Toshiyuki et al.

Chemico-Biological Interactions, 2011, 194(1), 23-30

Permalink : https://hdl.handle.net/2115/47398

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アクセス権	open access
URI	https://hdl.handle.net/2115/47398
タイトル	Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells
著者	Seki, Sayaka ; Aoki, Miho ; Hosokawa, Toshiyuki ; Saito, Takeshi ; Masuma, Runa ; Komori, Miyako ; Kurasaki, Masaaki
著者名 Seki, Sayaka
著者名 Aoki, Miho
著者名 Hosokawa, Toshiyuki
著者名 Saito, Takeshi
著者名 Masuma, Runa
著者名 Komori, Miyako
著者名 Kurasaki, Masaaki
言語	英語
キーワード	Bisphenol-A
	PC12 cell
	MAPK
	ERK
	Neurite
	Nerve growth factor
発行日	2011-10-15
出版者	Elsevier Ireland
収録物名	Chemico-Biological Interactions
巻(号)	194(1)
ページ	23-30
抄録	An endocrine disrupter, bisphenol-A is widely used in the production of plastics and coatings. Recently, it was reported that bisphenol-A affected neurotransmitters in the mammalian brain. On the basis of these reports, it was considered that bisphenol-A affected neuronal differentiation. In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. When a low concentration of bisphenol-A was added to medium containing NGF, it inhibited neurite extension. In addition, to clarify whether bisphenol-A affects the early and late stages of the NGF-signaling pathway in cell differentiation, changes of phosphorylation of MAP kinases and cAMP-response element binding protein (CREB) in PC12 cells treated with and without BPA in medium containing NGF were investigated using western blot analysis. As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0009-2797
NCID	AA0060252X
関連情報	PMID 21871873
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.cbi.2011.08.001