Cell penetrating peptide-mediated systemic siRNA delivery to the liver

Hayashi, Yasuhiro; Yamauchi, Jun; Khalil, Ikramy A.; Kajimoto, Kazuaki; Akita, Hidetaka; Harashima, Hideyoshi

Cell penetrating peptide-mediated systemic siRNA delivery to the liver

Hayashi, Yasuhiro; Yamauchi, Jun; Khalil, Ikramy A. et al.

International Journal of Pharmaceutics, 2011, 419(1-2), 308-313

Permalink : https://hdl.handle.net/2115/47472

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アクセス権	open access
URI	https://hdl.handle.net/2115/47472
タイトル	Cell penetrating peptide-mediated systemic siRNA delivery to the liver
著者	Hayashi, Yasuhiro ; Yamauchi, Jun ; Khalil, Ikramy A. ; Kajimoto, Kazuaki ; Akita, Hidetaka ; Harashima, Hideyoshi
e-Rad_Researcher 30548178 著者名 Hayashi, Yasuhiro
著者名 Yamauchi, Jun
著者名 Khalil, Ikramy A.
著者名 Kajimoto, Kazuaki
著者名 Akita, Hidetaka
著者名 Harashima, Hideyoshi
言語	英語
キーワード	Cell penetrating peptide
	Octaarginine
	siRNA delivery
	Liver
発行日	2011-10-31
出版者	Elsevier B.V.
収録物名	International Journal of Pharmaceutics
巻(号)	419(1-2)
ページ	308-313
抄録	The cell-penetrating peptide (CPP) is one of the most attractive tools for efficiently delivering biomolecules to a target organelle. Here, we describe the use of octaarginine (R8)-modified lipid nanoparticles for the efficient and targeted in vivo delivery of siRNA to the liver. In this study, SR-BI (a scavenger receptor class B, member 1) was targeted by this nanoparticle. Our results demonstrate that R8-modified lipid nanoparticles can be used for the efficient and targeted delivery of liver siRNA to induce the specific knock-down of an endogenous gene with minimum liver toxicity and immune response, and that this CPP based technology holds considerable promise for further in vivo biological applications of siRNA.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0378-5173
関連情報	PMID 21827843
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ijpharm.2011.07.038