Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET

Yoshinaga, Keiichiro; Manabe, Osamu; Katoh, Chietsugu et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2010, 37(12), 2233-2241

Permalink : https://hdl.handle.net/2115/47526

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アクセス権
open access
URI
https://hdl.handle.net/2115/47526
タイトル
Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET
著者
Yoshinaga, Keiichiro ; Manabe, Osamu ; Katoh, Chietsugu ; Chen, Li ; Klein, Ran ; Naya, Masanao ; deKemp, Robert A. ; Williams, Kathryn ; Beanlands, Rob S. B. ; Tamaki, Nagara
e-Rad_Researcher
30435961
著者名
Yoshinaga, Keiichiro
著者名
Manabe, Osamu
著者名
Katoh, Chietsugu
著者名
Chen, Li
著者名
Klein, Ran
著者名
Naya, Masanao
著者名
deKemp, Robert A.
著者名
Williams, Kathryn
著者名
Beanlands, Rob S. B.
著者名
Tamaki, Nagara
言語
英語
キーワード
Blood flow
Endothelium
Positron emission tomography
Smoking
発行日
2010-12
出版者
Springer Berlin / Heidelberg
収録物名
European Journal of Nuclear Medicine and Molecular Imaging
巻(号)
37(12)
ページ
2233-2241
抄録
Purpose: Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rubidium-82 (82Rb) is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET and ii) compare the results with those measured using 15O-water PET. Methods: MBF was assessed at rest and during CPT with 82Rb and 15O-water in 9 controls and 10 smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during CPT to MBF at rest. Results: At rest, measurements of MBF for smokers vs. controls were not different using 15O-water (0.86 ± 0.18 vs. 0.70 ± 0.13, p = 0.426) than they were using 82Rb (0.83 ± 0.23 vs. 0.62 ± 0.20, p = 0.051). Both methods showed a reduced CPT response in smokers vs. controls (15O-water, 1.03 ± 0.21 vs. 1.42 ± 0.29, p = 0.006; 82Rb, 1.02 ± 0.28 vs. 1.70 ± 0.52, p < 0.001). There was high reliability [intra-class correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during CPT. Conclusions: Using CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The original publication is available at www.springerlink.com
PISSN
1619-7070
関連情報
PMID
20625721
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s00259-010-1541-y