A Case of Follicular Bronchiolitis Associated with Asthma, Eosinophilia, and Increased Immunoglobulin E

Shimizu, Kaoruko; Konno, Satoshi; Nasuhara, Yasuyuki; Tanino, Mishie; Matsuno, Yoshihiro; Nishimura, Masaharu

A Case of Follicular Bronchiolitis Associated with Asthma, Eosinophilia, and Increased Immunoglobulin E

Shimizu, Kaoruko; Konno, Satoshi; Nasuhara, Yasuyuki et al.

Journal of Asthma, 2010, 47(10), 1161-1164

Permalink : https://hdl.handle.net/2115/47551

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アクセス権	open access
URI	https://hdl.handle.net/2115/47551
タイトル	A Case of Follicular Bronchiolitis Associated with Asthma, Eosinophilia, and Increased Immunoglobulin E
著者	Shimizu, Kaoruko ; Konno, Satoshi ; Nasuhara, Yasuyuki ; Tanino, Mishie ; Matsuno, Yoshihiro ; Nishimura, Masaharu
e-Rad_Researcher 40399853 著者名 Shimizu, Kaoruko
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
e-Rad_Researcher 30322811 著者名 Nasuhara, Yasuyuki
e-Rad_Researcher 90360908 著者名 Tanino, Mishie
e-Rad_Researcher 00199829 著者名 Matsuno, Yoshihiro
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	asthma
	eosinophilia
	follicular bronchiolitis
	IgE
	MALT lymphoma
発行日	2010-12
出版者	Informa Healthcare
収録物名	Journal of Asthma
巻(号)	47(10)
ページ	1161-1164
抄録	A 49-year-old woman, who had been diagnosed with asthma, showed a bilateral diffuse pattern of small centrilobular nodules on CT. Laboratory data revealed peripheral eosinophilia and a marked increase in total serum IgE levels. The nodules detected on CT were initially considered to be associated with bronchiolar infiltration of eosinophils. Pathological findings from thoracoscopy revealed infiltration of eosinophils into the airway lumen and walls, goblet cell hyperplasia, and thickening of the basement membrane in large bronchi, consistent with asthma. However, hyperplastic lymphoid follicles with reactive germinal centers were observed along the bronchioles. The follicles had no evidence of monoclonality suggested by immunohistological analysis, and no remarkable infiltrates of eosinophils, suggesting follicular bronchiolitis. After treatment with prednisolone, the small diffuse nodules improved markedly, and peripheral eosinophilia and total serum IgE levels also decreased. To the best of our knowledge, this is the first documented case report of follicular bronchiolitis associated with asthma, eosinophilia, and elevated IgE with a definite pathophysiological diagnosis.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Copyright © 2010 Informa Plc.
PISSN	0277-0903
関連情報	PMID 21039211
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.3109/02770903.2010.515326