Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger

Higa, Tsunaki; Horinouchi, Takahiro; Aoyagi, Hiroyuki et al.

Journal of Pharmacological Sciences, 2010, 113(3), 276-280

Permalink : https://hdl.handle.net/2115/47620

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アクセス権
open access
URI
https://hdl.handle.net/2115/47620
タイトル
Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger
著者
Higa, Tsunaki ; Horinouchi, Takahiro ; Aoyagi, Hiroyuki ; Asano, Hiroshi ; Nishiya, Tadashi ; Nishimoto, Arata ; Muramatsu, Ikunobu ; Miwa, Soichi
著者名
Higa, Tsunaki
e-Rad_Researcher
20307771
著者名
Horinouchi, Takahiro
著者名
Aoyagi, Hiroyuki
著者名
Asano, Hiroshi
著者名
Nishiya, Tadashi
著者名
Nishimoto, Arata
著者名
Muramatsu, Ikunobu
著者名
Miwa, Soichi
言語
英語
キーワード
endothelin type B receptor
Na+/H+ exchanger
p38 mitogen-activated protein kinase
発行日
2010-07
出版者
Japanese Pharmacological Society
収録物名
Journal of Pharmacological Sciences
巻(号)
113(3)
ページ
276-280
抄録
The mechanism for sustained Ca2+ influx activated by G protein-coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a sustained Ca2+ influx depending on Gq/11 protein, phospholipase C (PLC), Na+/H+ exchanger (NHE) and p38 mitogen-activated protein kinase (p38MAPK), whereas P2Y-R-induced sustained Ca2+ influx was negligible. Functional study showed that NHE activation by ETBR was mediated via p38MAPK but not Gq/11/PLC, while that by P2Y-R involves only Gq/11/PLC/p38MAPK. These results suggest that Gq/11/PLC-independent NHE activation via p38MAPK plays an important role in ETBR-mediated sustained Ca2+ influx.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1347-8613
EISSN
1347-8648
関連情報
URI
http://www.jstage.jst.go.jp/browse/jphs
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1254/jphs.10102SC