Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering

Trirongjitmoah, Suchin; Sakurai, Toshihiro; Iinaga, Kazuya et al.

Optics Express, 2010, 18(6), 6315-6326

Permalink : https://hdl.handle.net/2115/47804

このアイテムのアクセス数:1,046件（2026-02-08 16:35 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
OE18-6_6315-6326 pdf 232 KB 1,429

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/47804
タイトル
Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering
著者
Trirongjitmoah, Suchin ; Sakurai, Toshihiro ; Iinaga, Kazuya ; Chiba, Hitoshi ; Shimizu, Koichi
著者名
Trirongjitmoah, Suchin
著者名
Sakurai, Toshihiro
著者名
Iinaga, Kazuya
著者名
Chiba, Hitoshi
e-Rad_Researcher
30125322
著者名
Shimizu, Koichi
言語
英語
発行日
2010-03-15
出版者
Optical Society of America
収録物名
Optics Express
巻(号)
18(6)
ページ
6315-6326
抄録
Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-of-care testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
©2010 Optical Society of America
EISSN
1094-4087
関連情報
PMID
20389654
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1364/OE.18.006315