open access

https://hdl.handle.net/2115/47945

Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment

英語

15O positron emission tomography

2011-01

Lippincott Williams & Wilkins

Nuclear Medicine Communications

32(1)

63-70

Objective: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. However, the partition coefficient may change in pathological conditions. The purpose of this study was to investigate the changes of partition coefficient of water in pathological regions and its effect on regional CBF assessment. Methods: Study protocol included 22 patients with occlusive cerebrovascular disease to compare partition coefficients among 3 regions (infarction, non-infarct hypoperfusion, and contralateral) in the pathologic brain (analysis A), and to compare CBF estimated using fixed partition coefficient (CBF fixed) and CBF estimated using floating partition coefficients (CBF float)(analysis B). Results: Partition coefficient in the infarction (0.55 ± 0.07 ml/g) was lower than that in contralateral normal cortex (0.68 ± 0.05 ml/g), whereas non-infarct hypoperfusion did not show a significant change (0.67 ± 0.06 ml/g). As a result, use of a fixed partition coefficient of normal volunteers (0.70 ml/g) resulted in an underestimation in rCBF by 12% in infarction area (P<0.05), while estimation errors were smaller and induced no significant difference in non-infarct hypoperfusion area or in contralateral areas. Conclusions: Partition coefficient is stable except for the infarction, and CBF estimation using a fixed partition coefficient of normal volunteers provides clinically appreciable information in patients with cerebrovascular disease.

学術雑誌論文

Accepted Manuscript

This is a non-final version of an article published in final form in Nuclear Medicine Communications, Jan. 2011, 32(1), 63-70

0143-3636