Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats

Ochiai, K.; Yoshikawa, Y.; Oonuma, T. et al.

The Veterinary Journal, 2011, 190(2), 293-295

Permalink : https://hdl.handle.net/2115/47982

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アクセス権	open access
URI	https://hdl.handle.net/2115/47982
タイトル	Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats
著者	Ochiai, K. ; Yoshikawa, Y. ; Oonuma, T. ; Tomioka, Y. ; Hashizume, K. ; Morimatsu, M.
著者名 Ochiai, K.
著者名 Yoshikawa, Y.
著者名 Oonuma, T.
著者名 Tomioka, Y.
著者名 Hashizume, K.
著者名 Morimatsu, M.
言語	英語
キーワード	Canine
	BRCA2
	RAD51
発行日	2011-11
出版者	Elsevier
収録物名	The Veterinary Journal
巻(号)	190(2)
ページ	293-295
抄録	In humans, mutations of the breast cancer susceptibility protein BRCA2 interact with recombinase RAD51 and increase the risk of cancer. This interaction occurs via a series of eight BRC repeat sequences in BRCA2. A mammalian two-hybrid assay using individual BRC repeats demonstrated that all the repeats except BRC6 bind RAD51 strongly (BRC1, 2 and 4), with intermediate strength (BRC8), or weakly (BRC3, 5 and 7). In serial deletion mutation experiments, the binding strengths were increased when the C-terminal BRC repeat was removed from BRC1-8, BRC1-5 and BRC1-3. These results provide an understanding of the basic function of canine BRCA2 and may be helpful to estimate the effect of missense or truncation mutations in canine mammary tumours.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1090-0233
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tvjl.2010.11.001