Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons

Nakazawa, Shiori; Gotoh, Naoya; Matsumoto, Hirotaka; Murayama, Chiaki; Suzuki, Toshiharu; Yamamoto, Tohru

Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons

Nakazawa, Shiori; Gotoh, Naoya; Matsumoto, Hirotaka et al.

Journal of Histochemistry & Cytochemistry, 2011, 59(2), 202-213

Permalink : https://hdl.handle.net/2115/48172

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アクセス権	open access
URI	https://hdl.handle.net/2115/48172
タイトル	Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons
著者	Nakazawa, Shiori ; Gotoh, Naoya ; Matsumoto, Hirotaka ; Murayama, Chiaki ; Suzuki, Toshiharu ; Yamamoto, Tohru
著者名 Nakazawa, Shiori
著者名 Gotoh, Naoya
著者名 Matsumoto, Hirotaka
著者名 Murayama, Chiaki
著者名 Suzuki, Toshiharu
著者名 Yamamoto, Tohru
言語	英語
キーワード	sorting nexin
	SNX18
	SNX9-family
	motor neuron
	DRG neuron
	growth cone
発行日	2011-02
出版者	Sage Publications
収録物名	Journal of Histochemistry & Cytochemistry
巻(号)	59(2)
ページ	202-213
抄録	The sorting nexin (SNX) family proteins, which contain a Phox homology (PX) domain, play crucial roles in regulating the intracellular membrane trafficking of the endocytic pathway. The proper coordination of this pathway is important for axonal elongation; however, little is known about the expression and intracellular dynamics of the SNX members during the formation of the nervous system. Here we found that SNX18, which belongs to the Src-homology-3-PX-Bin/Amphiphysin/Rvs domain-containing SNX subfamily, was specifically expressed in differentiating motor neurons in the chick and mouse embryonic spinal cord. The expression of SNX18 in embryonic spinal motor neurons was transient and was down-regulated as the neurons matured. We further demonstrated that the localization of EGFP-SNX18 in growth cones was dynamically regulated and accumulated especially at areas in contact with permissive substrates. Our findings collectively suggest that SNX18 may play an active role in axonal elongation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final, definitive version of this article has been published in the Journal, Journal of Histochemistry & Cytochemistry, 59(2), 2011 of publication, © The Author(s) 2011 by SAGE Publications Ltd at the Journal of Histochemistry & Cytochemistry page: http://jhc.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/
PISSN	0022-1554
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1369/0022155410392231