Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma

Nakanishi, Yoshitsugu; Kondo, Satoshi; Zen, Yoh et al.

Journal of Hepato-Biliary-Pancreatic Sciences, 2010, 17(2), 166-173

Permalink : https://hdl.handle.net/2115/48196

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アクセス権
open access
URI
https://hdl.handle.net/2115/48196
タイトル
Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma
著者
Nakanishi, Yoshitsugu ; Kondo, Satoshi ; Zen, Yoh ; Yonemori, Atsuya ; Kubota, Kanako ; Kawakami, Hiroshi ; Tanaka, Eiichi ; Hirano, Satoshi ; Itoh, Tomoo ; Nakanuma, Yasuni
著者名
Nakanishi, Yoshitsugu
e-Rad_Researcher
30215454
著者名
Kondo, Satoshi
e-Rad_Researcher
90377416
著者名
Zen, Yoh
著者名
Yonemori, Atsuya
著者名
Kubota, Kanako
e-Rad_Researcher
80399823
著者名
Kawakami, Hiroshi
e-Rad_Researcher
60374279
著者名
Tanaka, Eiichi
e-Rad_Researcher
50322813
著者名
Hirano, Satoshi
e-Rad_Researcher
20301880
著者名
Itoh, Tomoo
e-Rad_Researcher
10115256
著者名
Nakanuma, Yasuni
言語
英語
キーワード
carcinoma in situ
superficial spread
extrahepatic bile duct carcinoma
prognosis
発行日
2010-03
出版者
Springer Japan
収録物名
Journal of Hepato-Biliary-Pancreatic Sciences
巻(号)
17(2)
ページ
166-173
抄録
Purpose: The aim of this study was to determine the impact of the presence of carcinoma in situ at the bile duct stump on postoperative survival in patients who underwent resection of extrahepatic bile duct carcinoma. Methods: The patients with resected extrahepatic bile duct carcinoma were divided into three groups according to resected margin status: no evidence of residual carcinoma (Negative group, n=96); carcinoma in situ at the bile duct stump (CIS group, n=10); and invasive carcinoma at any surgical margin (Invasive group, n=19). Cause-specific survival for these groups was compared statistically. Results: Surgical margin status was identified as a prognostic factor on univariate analysis (p=0.005) and was an independent prognostic factor on multivariate analysis (p=0.018). The CIS group displayed significantly better survival than the Invasive group (p=0.006), and the survival was comparable to that for the Negative group (p=0.533). Two of three patients in the CIS group with local recurrence died >5 years after surgical resection. Conclusions: Patients with positive ductal margins of carcinoma in situ of the extrahepatic bile duct do not appear to show different survival after resection compared to patients with negative margins, but remnant carcinoma in situ is likely to develop late local recurrence.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The original publication is available at www.springerlink.com
PISSN
1868-6974
EISSN
1868-6982
関連情報
PMID
19521656
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s00534-009-0127-1