Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases

Kamiya, Hiroyuki

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2010, 703(1), 32-36

Permalink : https://hdl.handle.net/2115/48353

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アクセス権
open access
URI
https://hdl.handle.net/2115/48353
タイトル
Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases
著者
e-Rad_Researcher
10204629
著者名
Kamiya, Hiroyuki
言語
英語
キーワード
oxidized DNA precursor
8-Hydroxy-dGTP
2-Hydroxy-dATP
Translesion synthesis DNA polymerase
Nucleotide pool sanitization enzyme
DNA repair enzyme
発行日
2010-11-28
出版者
Elsevier B.V.
収録物名
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
巻(号)
703(1)
ページ
32-36
抄録
The base moieties of DNA precursors in the nucleotide pool are subjected to oxidative damage, and the formation of damaged DNA precursors is an important source of mutagenesis. 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate, also known by the name of its keto-enol tautomer as 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, and 2-hydroxy-2'-deoxyadenosine 5'-triphosphate have been identified as the major products of in vitro oxidation reactions. The mutagenicities of these damaged precursors in living cells will be summarized in this review. In addition, the roles of the nucleotide pool sanitization and DNA repair enzymes, and the translesion synthesis DNA polymerases will be described.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1383-5718
関連情報
PMID
20542139
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.mrgentox.2010.06.003