Isolation of fucoxanthin and fatty acids analysis of Padina australis and cytotoxic effect of fucoxanthin on human lung cancer (H1299) cell lines

Jaswir, Irwandi; Noviendri, Dedi; Salleh, Hamzah Mohd. et al.

African Journal of Biotechnology, 2011, 10(81), 18855-18862

Permalink : https://hdl.handle.net/2115/48392

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アクセス権
open access
URI
https://hdl.handle.net/2115/48392
タイトル
Isolation of fucoxanthin and fatty acids analysis of Padina australis and cytotoxic effect of fucoxanthin on human lung cancer (H1299) cell lines
著者
Jaswir, Irwandi ; Noviendri, Dedi ; Salleh, Hamzah Mohd. ; Taher, Muhammad ; Miyashita, Kazuo
著者名
Jaswir, Irwandi
著者名
Noviendri, Dedi
著者名
Salleh, Hamzah Mohd.
著者名
Taher, Muhammad
e-Rad_Researcher
10182015
著者名
Miyashita, Kazuo
言語
英語
キーワード
Brown seaweed
Padina australis
fucoxanthin
fatty acid methyl ester
H1299 cell lines
human lung cancer
MTT assay
発行日
2011-12-16
出版者
Academic Journals
収録物名
African Journal of Biotechnology
巻(号)
10(81)
ページ
18855-18862
抄録
Fucoxanthin has been successfully isolated from species of Malaysian brown seaweed, namely Padina australis. The purity of the fucoxanthin is >98% as indicated by high performance liquid chromatography analysis. This seaweed also contains a considerable amount of unsaturated fatty acids. Thirteen fatty acids were detected with gas chromatography. However, fatty acid methyl ester (FAMEs) of eicosapentanoic acid (C20:5n-3), arachidonic acid (C20:4n-6), linoleic acid (C18:2n-6) and alpha-linolenic acid (C18:3n-3) contents of P. australis were found to be 2.06, 9.50, 6.37, and 2.83%, respectively. For saturated fatty acids, palmitic acid (C16:0) was found to be the major fatty acid with about 23.97%. Furthermore, data obtained from the methyl thiazolyl tetrazolium (MTT) assay indicated that fucoxanthin reduced the viability of H1299 cell lines, showing an IC50 value of 2.45 mM.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 3.0 Unported
PISSN
1684-5315
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.5897/AJB11.2765