A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations

Matsukawa, Toshihiro; Goto, Hideki; Takahashi, Kenta; Asanuma, Shinsuke; Yasumoto, Atsushi; Takahata, Mutsumi; Shigematsu, Akio; Endo, Tomoyuki; Tanaka, Junji; Hashino, Satoshi; Tanaka, Shinya; Imamura, Masahiro

A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations

Matsukawa, Toshihiro; Goto, Hideki; Takahashi, Kenta et al.

International Journal of Hematology, 2012, 95(2), 217-222

Permalink : https://hdl.handle.net/2115/48608

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アクセス権	open access
URI	https://hdl.handle.net/2115/48608
タイトル	A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations
著者	Matsukawa, Toshihiro ; Goto, Hideki ; Takahashi, Kenta ; Asanuma, Shinsuke ; Yasumoto, Atsushi ; Takahata, Mutsumi ; Shigematsu, Akio ; Endo, Tomoyuki ; Tanaka, Junji ; Hashino, Satoshi ; Tanaka, Shinya ; Imamura, Masahiro
著者名 Matsukawa, Toshihiro
著者名 Goto, Hideki
著者名 Takahashi, Kenta
著者名 Asanuma, Shinsuke
著者名 Yasumoto, Atsushi
著者名 Takahata, Mutsumi
著者名 Shigematsu, Akio
著者名 Endo, Tomoyuki
著者名 Tanaka, Junji
著者名 Hashino, Satoshi
著者名 Tanaka, Shinya
著者名 Imamura, Masahiro
言語	英語
キーワード	Cytomegalovirus ventriculoencephalitis
	Ganciclovir resistance
	Umbilical cord blood transplantation
	Mycosis fungoides
	Inclusion-bearing cells
発行日	2012-02
出版者	Springer Japan
収録物名	International Journal of Hematology
巻(号)	95(2)
ページ	217-222
抄録	Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old female patient with mycosis fungoides who underwent umbilical cord blood transplantation three times and developed CMV ventriculoencephalitis. The patient's CMV viremia was successfully preempted with ganciclovir (GCV) as indicated by undetectable CMV antigenemia, but despite this successful treatment, the patient developed CMV ventriculoencephalitis. Foscarnet (FCV) therapy led to a temporary recovery, after which CMV ventriculoencephalitis recurred and the patient died after receiving combination GCV and FCV therapy. Autopsy samples revealed CMV ventriculoencephalitis, as indicated by numerous inclusion-bearing cells (Owl's eye). It is likely that this patient harbored a GCV-resistant CMV strain; however, it was not possible to obtain nucleic acids suitable for use in assessing this possibility.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at www.springerlink.com
PISSN	0925-5710
関連情報	PMID 22262140
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12185-012-1003-3