Frequency of Chlamydia trachomatis in Ureaplasma-positive healthy women attending their first prenatal visit in a community hospital in Sapporo, Japan

Yamazaki, Tomohiro; Matsumoto, Megumi; Matsuo, Junji; Abe, Kiyotaka; Minami, Kunihiro; Yamaguchi, Hiroyuki

Frequency of Chlamydia trachomatis in Ureaplasma-positive healthy women attending their first prenatal visit in a community hospital in Sapporo, Japan

Yamazaki, Tomohiro; Matsumoto, Megumi; Matsuo, Junji et al.

BMC Infectious Diseases, 2012, 12(1), 82

Permalink : https://hdl.handle.net/2115/48735

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アクセス権	open access
URI	https://hdl.handle.net/2115/48735
タイトル	Frequency of Chlamydia trachomatis in Ureaplasma-positive healthy women attending their first prenatal visit in a community hospital in Sapporo, Japan
著者	Yamazaki, Tomohiro ; Matsumoto, Megumi ; Matsuo, Junji ; Abe, Kiyotaka ; Minami, Kunihiro ; Yamaguchi, Hiroyuki
著者名 Yamazaki, Tomohiro
著者名 Matsumoto, Megumi
e-Rad_Researcher 50359486 著者名 Matsuo, Junji
著者名 Abe, Kiyotaka
著者名 Minami, Kunihiro
e-Rad_Researcher 40221650 著者名 Yamaguchi, Hiroyuki
言語	英語
キーワード	Chlamydia trachomatis
	Ureaplasma urealyticum
	Ureaplasma parvum
	Mixed infection
	PCR
発行日	2012-04-02
収録物名	BMC Infectious Diseases
巻(号)	12(1)
ページ	82
抄録	[Background] Although Chlamydia trachomatis is the most commonly reported pathogen that causes urogenital infection such as urethritis or cervicitis, Ureaplasma parvum and Ureaplasma urealyticum, which are commensals in the genital tract, have also now been recognized as contributors to urogenital infection. However, whether the presence of either U. parvum or U. urealyticum is related to that of C. trachomatis in the urogenital tract remains unknown. We therefore attempted to estimate by PCR the prevalence of C. trachomatis, U. parvum and U. urealyticum in endocervical samples obtained from healthy women attending their first prenatal visit in Sapporo, Japan. [Methods] The samples were taken from 303 apparently healthy women, and the extracted DNAs (n = 280) were used for PCR detection targeting C. trachomatis, U. parvum and U. urealyticum. Statistical analysis of the data was performed by Fisher’s exact test. [Results] PCR detection revealed that the prevalence of C. trachomatis, U. parvum and U. urealyticum was 14.3% (40/280), 41.7% (117/280) and 8.9% (25/280), respectively. C. trachomatis ompA genotype D was most frequently identified. Surprisingly, either C. trachomatis or Ureaplasma spp. was detected in almost half of the healthy women. Mixed infection of C. trachomatis with either U. parvum or U. urealyticum was also observed in 9.2% (26/280) of the women. There was a significant association between C. trachomatis and either U. parvum (p = 0.023) or Ureaplasma total (p = 0.013), but not U. urealyticum (p = 0.275). [Conclusion] This study demonstrated that the presence of Ureaplasma had a significant effect on the presence of C. trachomatis in the genital tract of healthy women, suggesting that mixed infection is an important factor in bacterial pathogenesis in the genital tract.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-ShareAlike 2.1 Japan
PISSN	1471-2334
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/1471-2334-12-82