Effects of Maternal 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population

Yila, Thamar Ayo; Sasaki, Seiko; Miyashita, Chihiro; Braimoh, Titilola Serifat; Kashino, Ikuko; Kobayashi, Sumitaka; Okada, Emiko; Baba, Toshiaki; Yoshioka, Eiji; Minakami, Hisanori; Endo, Toshiaki; Sengoku, Kazuo; Kishi, Reiko

Effects of Maternal 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population

Yila, Thamar Ayo; Sasaki, Seiko; Miyashita, Chihiro et al.

Journal of Epidemiology, 2012, 22(2), 91-102

Permalink : https://hdl.handle.net/2115/48968

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アクセス権	open access
URI	https://hdl.handle.net/2115/48968
タイトル	Effects of Maternal 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population
著者	Yila, Thamar Ayo ; Sasaki, Seiko ; Miyashita, Chihiro ; Braimoh, Titilola Serifat ; Kashino, Ikuko ; Kobayashi, Sumitaka ; Okada, Emiko ; Baba, Toshiaki ; Yoshioka, Eiji ; Minakami, Hisanori ; Endo, Toshiaki ; Sengoku, Kazuo ; Kishi, Reiko
著者名 Yila, Thamar Ayo
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Braimoh, Titilola Serifat
著者名 Kashino, Ikuko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
e-Rad_Researcher 00766537 著者名 Okada, Emiko
著者名 Baba, Toshiaki
e-Rad_Researcher 70435957 著者名 Yoshioka, Eiji
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
e-Rad_Researcher 90213595 著者名 Endo, Toshiaki
e-Rad_Researcher 30163124 著者名 Sengoku, Kazuo
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	birth weight
	tobacco smoking
	MTHFR SNPs
	folate
	Japan
発行日	2012
出版者	Japan Epidemiological Association
収録物名	Journal of Epidemiology
巻(号)	22(2)
ページ	91-102
抄録	Background: Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Because 5,10-MTHFR 677TT homozygosity and tobacco smoking are associated with low folate status, we tested the hypothesis that smoking in mothers with 5,10-MTHFR C677T or A1298C polymorphisms would be independently associated with lower birth weight among their offspring. Methods: We assessed 1784 native Japanese mother-child pairs drawn from the ongoing birth cohort of The Hokkaido Study on Environment and Children's Health. Data (demographic information, hospital birth records, and biological specimens) were extracted from recruitments that took place during the period from February 2003 to March 2006. Maternal serum folate were assayed by chemiluminescent immunoassay, and genotyping of 5,10-MTHFR C677T/A1298C polymorphisms was done using a TaqMan allelic discrimination assay. Results: The prevalence of folate deficiency (< 6.8 nmol/L) was 0.3%. The 5,10-MTHFR 677CT genotype was independently associated with an increase of 36.40 g (95% CI: 2.60 to 70.30, P = 0.035) in mean infant birth weight and an increase of 90.70 g (95% CI: 6.00 to 175.50, P = 0.036) among male infants of nonsmokers. Female infants of 677TT homozygous passive smokers were 99.00 g (95% CI: -190.26 to -7.56, P = 0.034) lighter. The birth weight of the offspring of smokers with 5,10-MTHFR 1298AA homozygosity was lower by 107.00 g (95% CI: -180.00 to -33.90, P = 0.004). Conclusions: The results suggest that, in this population, maternal 5,10-MTHFR C677T polymorphism, but not the 5,10-MTHFR A1298C variant, is independently associated with improvement in infant birth weight, especially among nonsmokers. However, 5,10-MTHFR 1298AA might be associated with folate impairment and could interact with tobacco smoke to further decrease birth weight.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright © 2012 by the Japan Epidemiological Association
PISSN	0917-5040
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2188/jea.JE20110039