Inhibitory Potencies of Bromophenols from Rhodomelaceae algae against α-Glucosidase Activity

Kurihara, Hideyuki; Mitani, Takeshi; Kawabata, Jun; Takahashi, Koretaro

Inhibitory Potencies of Bromophenols from Rhodomelaceae algae against α-Glucosidase Activity

Kurihara, Hideyuki; Mitani, Takeshi; Kawabata, Jun et al.

Fisheries Science, 1999, 65(2), 300-303

Permalink : https://hdl.handle.net/2115/48990

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アクセス権	open access
URI	https://hdl.handle.net/2115/48990
タイトル	Inhibitory Potencies of Bromophenols from Rhodomelaceae algae against α-Glucosidase Activity
著者	Kurihara, Hideyuki ; Mitani, Takeshi ; Kawabata, Jun ; Takahashi, Koretaro
e-Rad_Researcher 40234570 著者名 Kurihara, Hideyuki
著者名 Mitani, Takeshi
e-Rad_Researcher 60142197 著者名 Kawabata, Jun
e-Rad_Researcher 90125328 著者名 Takahashi, Koretaro
言語	英語
キーワード	Symphyocladia latiuscula
	Odonthalia corymbifera
	Polysiphonia morrowii
	Rhodomelaceae
	α-glucosidase
	inhibition
	bromophenol
発行日	1999
出版者	Japanese Society of Fisheries Science
収録物名	Fisheries Science
巻(号)	65(2)
ページ	300-303
抄録	Inhibitory potencies against α-glucosidase activities were compared among bromophenols obtained from extracts of three Rhodomelaceae red algae, Symphyocladia latiuscula, Odonthalia corymbifera, and Polysiphonia morrowii. The bromophenols from these species are characterized by a number of Br atoms per benzene ring: S. latiuscula, three Br atoms (1 and 2); O. corymbifera, two Br atoms (3-7); and P. morrowii, one Br atom (8 and 9). The bromophenols exhibited mixed inhibition against yeast α-glucosidase reaction. In particular, symmetric dibenzyl ethers, bis(2,3,6-tribromo-4,5-dihydroxybenzyl) ether (2) and bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (5), exhibited about 10^3 fold smaller K_i values than the other bromophenols. Their inhibition modes are disclosed to be mixed inhibition closed to competitive inhibition. Inhibitory potencies of the bromophenols increased with the increasing degree of bromo-substitution per benzene ring and the decreasing degree of methyl-substitution. In contrast to the strong inhibitory activity against yeast α-glucosidase activity, the bromophenols moderately inhibited rat-intestinal sucrase and maltase activity. The inhibitory potencies were all comparative among the bromophenols examined.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0919-9268
NCID	AA10993718
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2331/fishsci.65.300