Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus

Yabe, Ichiro; Tsuji-Akimoto, Sachiko; Shiga, Tohru; Hamada, Shinsuke; Hirata, Kenji; Otsuki, Mika; Kuge, Yuji; Tamaki, Nagara; Sasaki, Hidenao

Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus

Yabe, Ichiro; Tsuji-Akimoto, Sachiko; Shiga, Tohru et al.

Journal of the neurological sciences, 2012, 315(1-2), 55-59

Permalink : https://hdl.handle.net/2115/49001

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アクセス権	open access
URI	https://hdl.handle.net/2115/49001
タイトル	Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus
著者	Yabe, Ichiro ; Tsuji-Akimoto, Sachiko ; Shiga, Tohru ; Hamada, Shinsuke ; Hirata, Kenji ; Otsuki, Mika ; Kuge, Yuji ; Tamaki, Nagara ; Sasaki, Hidenao
e-Rad_Researcher 60372273 著者名 Yabe, Ichiro
著者名 Tsuji-Akimoto, Sachiko
e-Rad_Researcher 80374495 著者名 Shiga, Tohru
著者名 Hamada, Shinsuke
e-Rad_Researcher 30431365 著者名 Hirata, Kenji
著者名 Otsuki, Mika
e-Rad_Researcher 70321958 著者名 Kuge, Yuji
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
e-Rad_Researcher 80281806 著者名 Sasaki, Hidenao
言語	英語
キーワード	Amyotrophic lateral sclerosis
	Writing error
	Cognitive dysfunction
	PET
	Anterior cingulate gyrus
発行日	2012-04-15
出版者	Elsevier
収録物名	Journal of the neurological sciences
巻(号)	315(1-2)
ページ	55-59
抄録	Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors. (11)C-flumazenil (FMZ), the positron emission tomography (PET) GABA(A) receptor ligand, is a marker of cortical dysfunction. The objective of this study was to investigate the relationship between cognitive deficits and loss of neuronal integrity in ALS patients using (11)C-FMZ PET. Ten patients with ALS underwent both neuropsychological tests and (11)C-FMZ-PET. The binding potential (BP) of FMZ was calculated from (11)C-FMZ PET images. There were no significant correlations between the BP and most test scores except for the writing error index (WEI), which was measured by the modified Western Aphasia Battery - VB (WAB-IVB) test. The severity of writing error was associated with loss of neuronal integrity in the bilateral anterior cingulate gyrus with mild right predominance (n=9; x=4mm, y=36mm, z=4mm, Z=5.1). The results showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0022-510X
NCID	AA00703265
関連情報	PMID 22226010
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jns.2011.11.039