CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection

Yamada, Noriyuki; Oizumi, Satoshi; Kikuchi, Eiki; Shinagawa, Naofumi; Konishi-Sakakibara, Jun; Ishimine, Atsushi; Aoe, Keisuke; Gemba, Kenichi; Kishimoto, Takumi; Torigoe, Toshihiko; Nishimura, Masaharu

CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection

Yamada, Noriyuki; Oizumi, Satoshi; Kikuchi, Eiki et al.

Cancer Immunology, Immunotherapy, 2010, 59(10), 1543-1549

Permalink : https://hdl.handle.net/2115/49187

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アクセス権	open access
URI	https://hdl.handle.net/2115/49187
タイトル	CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection
著者	Yamada, Noriyuki ; Oizumi, Satoshi ; Kikuchi, Eiki ; Shinagawa, Naofumi ; Konishi-Sakakibara, Jun ; Ishimine, Atsushi ; Aoe, Keisuke ; Gemba, Kenichi ; Kishimoto, Takumi ; Torigoe, Toshihiko ; Nishimura, Masaharu
著者名 Yamada, Noriyuki
e-Rad_Researcher 10421968 著者名 Oizumi, Satoshi
著者名 Kikuchi, Eiki
著者名 Shinagawa, Naofumi
著者名 Konishi-Sakakibara, Jun
著者名 Ishimine, Atsushi
著者名 Aoe, Keisuke
著者名 Gemba, Kenichi
著者名 Kishimoto, Takumi
著者名 Torigoe, Toshihiko
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	Malignant pleural mesothelioma
	HLA class I
	Tumor-infiltrating lymphocytes (TIL)
	Immunohistochemistry
	Immunotherapy
発行日	2010-10
出版者	Springer Berlin / Heidelberg
収録物名	Cancer Immunology, Immunotherapy
巻(号)	59(10)
ページ	1543-1549
抄録	Defects in human leukocyte antigen (HLA) class I expression may allow tumor cells to escape immune recognition. T-cell infiltration is associated with a good prognosis in many cancers. However, the role of HLA class I expression and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM) has not been fully analyzed. In the present study, we investigated the immune profiles and conducted outcome analyses of MPM patients. HLA class I expression and TILs (CD4+, CD8+, and NK cells) were detected by immunohistochemistry in a series of 44 MPM cases. To detect HLA class I expression, specimens were stained with the anti-pan HLA class I monoclonal antibody EMR8-5. The expression of HLA class I was positive in all patients. There was no case that showed negative HLA class I expression. The density of CD4+ and CD8+ TILs were strongly correlated (R = 0.76, p < 0.001). A high density of CD8+ TILs was a significantly better prognostic factor for the survival of patients with extrapleural pneumonectomy (p < 0.05). Multivariate analysis revealed that a high density of CD8+ TILs is an independent prognostic factor for patients who underwent extrapleural pneumonectomy. The presence of intratumoral CD8+ T cells was correlated with an improved clinical outcome, raising the possibility that CD8+ T cells might play a pivotal role in the anti-tumor immune response against MPMs. Thus, the stimulation of CD8+ lymphocytes might be an efficacious immunotherapy for MPM patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at www.springerlink.com
PISSN	0340-7004
EISSN	1432-0851
関連情報	PMID 20567822
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00262-010-0881-6