Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

Shimada, Kohei; Ohno, Yuta; Okamatsu-Ogura, Yuko; Suzuki, Masahiro; Kamikawa, Akihiro; Terao, Akira; Kimura, Kazuhiro

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

Shimada, Kohei; Ohno, Yuta; Okamatsu-Ogura, Yuko et al.

Peptides, 2012, 34(2), 336-342

Permalink : https://hdl.handle.net/2115/49225

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アクセス権	open access
URI	https://hdl.handle.net/2115/49225
タイトル	Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes
著者	Shimada, Kohei ; Ohno, Yuta ; Okamatsu-Ogura, Yuko ; Suzuki, Masahiro ; Kamikawa, Akihiro ; Terao, Akira ; Kimura, Kazuhiro
著者名 Shimada, Kohei
著者名 Ohno, Yuta
e-Rad_Researcher 90527178 著者名 Okamatsu-Ogura, Yuko
著者名 Suzuki, Masahiro
著者名 Kamikawa, Akihiro
e-Rad_Researcher 10451402 著者名 Terao, Akira
e-Rad_Researcher 30192561 著者名 Kimura, Kazuhiro
言語	英語
キーワード	BAT
	Norepinephrine
	p44/p42 MAPK
	NPY
	STAT
	Thermogenesis
発行日	2012-04
出版者	Elsevier
収録物名	Peptides
巻(号)	34(2)
ページ	336-342
抄録	The thermogenic function of brown adipose tissue (BAT) is increased by norepinephrine (NE) released from sympathetic nerve endings, but the roles of NPY released along with NE are poorly elucidated. Here, we examined effect of NPY on basal and NE-enhanced thermogenesis in isolated brown adipocytes that express Y1 and Y5 receptor mRNA. Treatment of cells with NPY did not influence the basal and NE-enhanced rates of oxygen consumption and cAMP accumulation. Treatment with NPY also failed to induce ERK (Thr202/Tyr204) phosphorylation in the brown adipocytes. In contrast, treatment with NPY increased ERK phosphorylation in cultured stromal vascular cells from the BAT that express Y1 receptor mRNA. In the latter treatment with NPY also increased STAT3 (Ser727) phosphorylation. These results suggest that NPY mainly acts on stromal vascular cells in BAT and plays roles in the regulation of their gene transcription through ERK and STAT3 pathways, while NPY does not affect the thermogenic function of brown adipocytes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0196-9781
関連情報	PMID 22374387
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.peptides.2012.02.012