Successful reduced-intensity SCT from unrelated cord blood in three patients with X-linked SCID

Iguchi, Akihiro; Kawamura, Nobuaki; Kobayashi, Ryoji; Takezaki, Shun-ichiro; Ohkura, Yuka; Inamoto, Jun; Ohshima, Junjiro; Ichikawa, Mizuho; Sato, Tomonobu; Kaneda, Makoto; Cho, Yuko; Yamada, Masafumi; Kobayashi, Ichiro; Ariga, Tadashi

Successful reduced-intensity SCT from unrelated cord blood in three patients with X-linked SCID

Iguchi, Akihiro; Kawamura, Nobuaki; Kobayashi, Ryoji et al.

Bone Marrow Transplantation, 2011, 46(12), 1526-1531

Permalink : https://hdl.handle.net/2115/49342

このアイテムのアクセス数:1,189件（2026-02-10 00:12 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
BMT46-12_1526-1531	pdf	680 KB	1,088

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/49342
タイトル	Successful reduced-intensity SCT from unrelated cord blood in three patients with X-linked SCID
著者	Iguchi, Akihiro ; Kawamura, Nobuaki ; Kobayashi, Ryoji ; Takezaki, Shun-ichiro ; Ohkura, Yuka ; Inamoto, Jun ; Ohshima, Junjiro ; Ichikawa, Mizuho ; Sato, Tomonobu ; Kaneda, Makoto ; Cho, Yuko ; Yamada, Masafumi ; Kobayashi, Ichiro ; Ariga, Tadashi
著者名 Iguchi, Akihiro
e-Rad_Researcher 90301879 著者名 Kawamura, Nobuaki
著者名 Kobayashi, Ryoji
著者名 Takezaki, Shun-ichiro
著者名 Ohkura, Yuka
著者名 Inamoto, Jun
著者名 Ohshima, Junjiro
著者名 Ichikawa, Mizuho
著者名 Sato, Tomonobu
著者名 Kaneda, Makoto
著者名 Cho, Yuko
著者名 Yamada, Masafumi
著者名 Kobayashi, Ichiro
e-Rad_Researcher 60322806 著者名 Ariga, Tadashi
言語	英語
キーワード	Stem cell transplantation (SCT)
	X-linked severe combined immunodeficiency (XSCID)
	reduced-intensity stem cell transplantation (RIST)
	cord blood (CB)
	fludarabine/busulfan
発行日	2011-12
出版者	Nature Publishing Group
収録物名	Bone Marrow Transplantation
巻(号)	46(12)
ページ	1526-1531
抄録	We described three boys with X-linked severe combined immunodeficiency (X-SCID) who were successfully treated by reduced-intensity stem cell transplantation from unrelated cord blood (CB). Mean age at the transplantation was 5.7 months (range, 3-9 months). Pre-transplantation conditioning for all patients consisted of fludarabine (FLU) (30 mg/m2/day) from day -7 to day -2 (total dose 180 mg/m2) and busulfan (BU) 4mg/kg/day from day -3 to day -2 (total dose 8 mg/kg). All of the CB units were serologically matched HLA-A, B, and DR loci. Although two of them had suffered from fungal or bacterial pneumonia before transplantation, there were no other infectious complications during transplantation. All the patients have engrafted and achieved 100% donor chimerism. We also confirmed full donor chimerism of both T and B cells. Only one patients developed acute GVHD grade III, which resolved by increasing the dose of oral corticosteroid. None of the patients have developed chronic GVHD during the follow up for 21 to 77 months. No patients had received intravenous immunoglobulin replacements after the transplantations, or showed delay in psychomotor development. Reduced-intensity conditioning consisting of FLU and BU and transplantation from unrelated CB was effective and safe treatment for patients with X-SCID.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0268-3369
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/bmt.2010.338