Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype

Tsukiyama, Tadasuke; Yamaguchi, Terry P.

Neuroscience Letters, 2012, 512(1), 48-52

Permalink : https://hdl.handle.net/2115/49420

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アクセス権	open access
URI	https://hdl.handle.net/2115/49420
タイトル	Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype
著者	e-Rad_Researcher 20399819 著者名 Tsukiyama, Tadasuke
著者	著者名 Yamaguchi, Terry P.
言語	英語
キーワード	Wnt
	Embryogenesis
	Brain
	Redundancy
	Olfactory bulb
発行日	2012-03-14
出版者	Elsevier Ireland
収録物名	Neuroscience Letters
巻(号)	512(1)
ページ	48-52
抄録	Wnts are secreted glycoproteins that play important roles in embryonic development. Wnt2b is transiently expressed in the primitive streak (PS) during gastrulation and in several organs during organogenesis. To determine the biological function of Wnt2b during mouse development, we established a conditional null allele of Wnt2b. Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length. Our results suggest that Wnt2b primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as Wnt2, in numerous tissues.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0304-3940
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.neulet.2012.01.062