Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells

Nakamura, Koichi; Deyama, Yoshiaki; Yoshimura, Yoshitaka; Hashimoto, Masanori; Kaga, Masayuki; Suzuki, Kuniaki; Yawaka, Yasutaka

Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells

Nakamura, Koichi; Deyama, Yoshiaki; Yoshimura, Yoshitaka et al.

Molecular Medicine Reports, 2011, 4(4), 641-644

Permalink : https://hdl.handle.net/2115/49476

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アクセス権	open access
URI	https://hdl.handle.net/2115/49476
タイトル	Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells
著者	Nakamura, Koichi ; Deyama, Yoshiaki ; Yoshimura, Yoshitaka ; Hashimoto, Masanori ; Kaga, Masayuki ; Suzuki, Kuniaki ; Yawaka, Yasutaka
著者名 Nakamura, Koichi
e-Rad_Researcher 80271667 著者名 Deyama, Yoshiaki
e-Rad_Researcher 30230816 著者名 Yoshimura, Yoshitaka
著者名 Hashimoto, Masanori
e-Rad_Researcher 70125300 著者名 Kaga, Masayuki
e-Rad_Researcher 40133748 著者名 Suzuki, Kuniaki
e-Rad_Researcher 60230603 著者名 Yawaka, Yasutaka
言語	英語
キーワード	tannin-fluoride preparation
	prostaglandin E2
	dental pulp cells
発行日	2011-07
出版者	Spandidos Publications
収録物名	Molecular Medicine Reports
巻(号)	4(4)
ページ	641-644
抄録	Glass ionomer cements (GICs) are widely used for the operative restoration of dental caries. However, it has been reported that the components of GICs cause pulpal inflammatory responses. Recently, GICs containing tannin-fluoride preparation (HY agent) were developed. In this study, we investigated the effect of HY agent on prostaglandin E2, (PGE2) release from GIC-stimulated rat dental pulp cells (RPC-C2A). Extracts derived from GIC disks were used with HY(+) and without HY(-) agent. After treatment with GIC extracts, ATP contents, COX-2 mRNA and protein expression in RPC-C2A cells, and PGE2 production in culture media were analyzed. HY agent suppressed HY(-)-stimulated PGE2 release from RPC-C2A cells, as well as COX-2 mRNA and protein expression. Moreover, tannic acid attenuated COX-2 mRNA induced by HY(-) extract in a dose-dependent manner. Taken together, these results suggest that tannic acid in HY agent may suppress GIC-induced production of PGE2 by inhibition of COX-2 expression in dental pulp cells.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1791-2997
関連情報	PMID 21503579
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/mmr.2011.476